Prieur A M, Piussan C, Manigne P, Bordigoni P, Griscelli C, Reinert P, de Goujon F, Lefur J M, Garnier J M
Arch Fr Pediatr. 1985 Feb;42(2):91-6.
Seventy-four children with juvenile chronic arthritis were admitted to a 6-month multicentric double blind comparative study of the efficiency of D-Penicillamine or placebo. The results evaluated in 55 patients who completed the study, indicated an improvement in the total number of stiff joints and in the total index of severity measuring joint pain and inflammation. A significant reduction of the concurrent use of non steroidal antiinflammatory drugs was also observed. The tolerance was good except in two patients. Some children in the placebo group exhibited a definite improvement.
74名青少年慢性关节炎患儿被纳入一项为期6个月的多中心双盲对照研究，以比较D-青霉胺与安慰剂的疗效。对完成研究的55名患者的评估结果显示，僵硬关节总数以及衡量关节疼痛和炎症的严重程度总指数均有所改善。同时还观察到非甾体抗炎药的使用量显著减少。除两名患者外，耐受性良好。安慰剂组的一些儿童也有明显改善。
