College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.
College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.
Int J Biol Macromol. 2024 Aug;274(Pt 1):133287. doi: 10.1016/j.ijbiomac.2024.133287. Epub 2024 Jun 22.
Inspired by the natural antimicrobial effect of the topographical features of insect wings, this study prepared urchin-like gold nanoparticles (UGNPs) and deposited them on poly(ε-caprolactone) (PCL)/chitosan (P/C) electrospun nanofiber film to strengthen antibacterial activities of this active packaging. Results showed that L-Dopa was a suitable reducing agent to prepare UGNPs, and the spine length of UGNPs increased from 21.23 to 35.83 nm as the molar ratio of L-Dopa:HAuCl increased from 1 to 3. As the nanofiber film was immersed in the nanoparticle solution for a longer time, the UGNP content in P/C nanofibers increased. As the spine length of UGNPs and depositing UGNP content increased, the inhibition rate against S. aureus and E. coli. of P/C nanofiber film increased. In addition, P/C nanofiber film deposited with UGNPs also exhibited good thermal stability, hydrophilicity, mechanical strength, and water vapor permeability, exhibiting its potential as an antibacterial active packaging.
受昆虫翅膀形貌的天然抗菌效果启发，本研究制备了仿刺猬状金纳米粒子（UGNPs）并将其沉积在聚（ε-己内酯）（PCL）/壳聚糖（P/C）静电纺纳米纤维膜上，以增强该活性包装的抗菌活性。结果表明，L-多巴是一种合适的还原剂来制备 UGNPs，并且随着 L-多巴：HAuCl 的摩尔比从 1 增加到 3，UGNPs 的刺长从 21.23nm 增加到 35.83nm。随着纳米纤维膜在纳米粒子溶液中浸泡时间的延长，P/C 纳米纤维中的 UGNP 含量增加。随着 UGNPs 的刺长和沉积 UGNP 含量的增加，P/C 纳米纤维膜对金黄色葡萄球菌和大肠杆菌的抑制率增加。此外，沉积 UGNPs 的 P/C 纳米纤维膜还表现出良好的热稳定性、亲水性、机械强度和水蒸气透过率，显示出其作为抗菌活性包装的潜力。
