Zhou Liuzhu, Cai Ling, Ruan Hongjie, Zhang Li, Wang Jun, Jiang Huijun, Wu Yuan, Feng Shanwu, Chen Jin
Center for Global Health, School of Public Health, Nanjing Medical University, 211166 Nanjing, China.
Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, 123 Tianfei Lane, Nanjing 210004, China.
Int J Biol Macromol. 2021 Jul 31;183:1145-1154. doi: 10.1016/j.ijbiomac.2021.05.031. Epub 2021 May 6.
Burn injury has posed devastating burdens on the public health due to its inevitable damage to the skin structure resulting in the increased risk of infection. Therefore, it is highly demanding to develop efficacious antibacterial wound-healing dressing. Despite the favourable wound-healing activities, the curative efficacy of phytochemical compounds of quercetin (Qe) and its derivatives is limited by their poor water solubility. Here, we have fabricated a novel electrospun nanofiber membrane (ENM) consisting of polycaprolactone (PCL), chitosan oligosaccharides (COS), and Qe/Rutin (Ru) as the potential bioactive dressing for wound healing. The incorporation of chitosan oligosaccharides (COSs) in the PCL scaffold at the optimized molar ratio not only contributed to the improved hydrophilicity and water absorption performance of the ENM but effectively increased the specific surface area of the formed nanofibers. In particular, the antioxidant and antibacterial activities of the Qe/rutin-loaded nanofiber membranes were tested, which revealed that the PCL-COS-Qe membrane exhibited superior performance among all nanofiber membranes. Therefore, the developed PCL-COS-Qe/Ru nanofiber membranes hold enormous potential as healthcare products, such as wound dressings for burn injuries.
烧伤因其对皮肤结构造成不可避免的损伤，增加感染风险，给公共卫生带来了毁灭性负担。因此，开发有效的抗菌伤口愈合敷料具有很高的需求。尽管槲皮素（Qe）及其衍生物的植物化学化合物具有良好的伤口愈合活性，但其治疗效果受到其水溶性差的限制。在此，我们制备了一种新型的电纺纳米纤维膜（ENM），它由聚己内酯（PCL）、壳寡糖（COS）和Qe/芦丁（Ru）组成，作为潜在的伤口愈合生物活性敷料。以优化的摩尔比将壳寡糖（COSs）掺入PCL支架中，不仅有助于提高ENM的亲水性和吸水性能，还能有效增加所形成纳米纤维的比表面积。特别是，对负载Qe/芦丁的纳米纤维膜的抗氧化和抗菌活性进行了测试，结果表明PCL-COS-Qe膜在所有纳米纤维膜中表现出优异的性能。因此，所开发的PCL-COS-Qe/Ru纳米纤维膜作为医疗保健产品，如烧伤伤口敷料，具有巨大的潜力。
