Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha 410008, Hunan, China; Sepsis Translational Medicine Key Lab of Hunan Province, Changsha 410008, Hunan, China; National Medicine Functional Experimental Teaching Center, Changsha 410008, Hunan, China.
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha 410008, Hunan, China; Sepsis Translational Medicine Key Lab of Hunan Province, Changsha 410008, Hunan, China; National Medicine Functional Experimental Teaching Center, Changsha 410008, Hunan, China.
Clin Immunol. 2024 Aug;265:110298. doi: 10.1016/j.clim.2024.110298. Epub 2024 Jun 22.
Prostaglandins (PGs) play a crucial and multifaceted role in various physiological processes such as intercellular signaling, inflammation regulation, neurotransmission, vasodilation, vasoconstriction, and reproductive functions. The diversity and biological significance of these effects are contingent upon the specific types or subtypes of PGs, with each PG playing a crucial role in distinct physiological and pathological processes. Particularly within the immune system, PGs are essential in modulating the function of immune cells and the magnitude and orientation of immune responses. Hence, a comprehensive comprehension of the functions PG signaling pathways in immunosuppressive regulation holds substantial clinical relevance for disease prevention and treatment strategies. The manuscript provides a review of recent developments in PG signaling in immunosuppressive regulation. Furthermore, the potential clinical applications of PGs in immunosuppression are also discussed. While research into the immunosuppressive effects of PGs required further exploration, targeted therapies against their immunosuppressive pathways might open new avenues for disease prevention and treatment.
前列腺素（PGs）在多种生理过程中发挥着至关重要且多方面的作用，如细胞间信号传递、炎症调节、神经递质传递、血管舒张、血管收缩和生殖功能。这些作用的多样性和生物学意义取决于特定类型或亚型的 PGs，每种 PG 在不同的生理和病理过程中都起着关键作用。特别是在免疫系统中，PG 对于调节免疫细胞的功能以及免疫反应的强度和方向至关重要。因此，全面了解 PG 信号通路在免疫抑制调节中的功能具有重要的临床意义，可用于疾病的预防和治疗策略。本文综述了 PG 信号在免疫抑制调节中的最新研究进展。此外，还讨论了 PG 在免疫抑制中的潜在临床应用。虽然需要进一步研究 PG 的免疫抑制作用，但针对其免疫抑制途径的靶向治疗可能为疾病的预防和治疗开辟新途径。
