Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510000, China.
Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510000, China.
Graefes Arch Clin Exp Ophthalmol. 2024 Oct;262(10):3345-3353. doi: 10.1007/s00417-024-06556-0. Epub 2024 Jun 24.
To validate the Graves ophthalmopathy quality of life (GO-QOL) questionnaire in screening DON and to construct an effective model.
A total of 194 GO patients were recruited and divided into DON and non-DON (mild and moderate-to-severe) groups. Eye examinations were performed, and quality of life was assessed by the GO-QOL questionnaire. The random forest, decision tree model, receiver operator characteristic (ROC) curve, accuracy and Brier score were determined by R software.
In GO-QOL, age, best corrected visual acuity (BCVA), exophthalmos, CAS, severity, and Gorman score were found to be factors related to visual function scores. On the appearance scale, gender, duration of GO, BCVA, exophthalmos, CAS and severity of GO were relevant. Both the visual function scores and appearance scores were significantly lower in DON groups than in non-DON groups (33.18 ± 24.54 versus 81.26 ± 17.39, 60.08 ± 24.82 versus 76.14 ± 27.56). The sensitivity, specificity, and AUC of the visual function scores were 91.1%, 81.7% and 0.939, respectively Visual function scores were used to construct a decision tree model. The sensitivity, specificity, and AUC of the model were 92.9%, 88.0% and 0.941, respectively, with an accuracy of 89.7% and a Brier score of 0.024.
Visual function scores were qualified as a screening method for DON, with a cutoff point of 58. A multifactorial screening model based on visual function scores was constructed.
验证格雷夫斯眼病生活质量（GO-QOL）问卷在诊断甲状腺眼病相关视神经病变（DON）中的作用，并构建有效的模型。
共招募 194 例 GO 患者，分为 DON 和非 DON（轻中度和中重度）组。进行眼部检查，使用 GO-QOL 问卷评估生活质量。使用 R 软件确定随机森林、决策树模型、接收者操作特征（ROC）曲线、准确率和 Brier 评分。
在 GO-QOL 中，年龄、最佳矫正视力（BCVA）、突眼度、CAS、严重程度和 Gorman 评分与视觉功能评分相关。在外观量表上，性别、GO 病程、BCVA、突眼度、CAS 和 GO 严重程度与评分相关。DON 组的视觉功能评分和外观评分均明显低于非 DON 组（33.18±24.54 与 81.26±17.39，60.08±24.82 与 76.14±27.56）。视觉功能评分的灵敏度、特异度和 AUC 分别为 91.1%、81.7%和 0.939。使用视觉功能评分构建决策树模型，模型的灵敏度、特异度和 AUC 分别为 92.9%、88.0%和 0.941，准确率为 89.7%，Brier 评分 0.024。
视觉功能评分可作为 DON 的筛查方法，截断值为 58。构建了基于视觉功能评分的多因素筛查模型。
