College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Cells. 2023 Jul 3;12(13):1767. doi: 10.3390/cells12131767.
Depression is a common neuropsychiatric disorder with long-term recurrent depressed mood, pain and despair, pessimism and anxiety, and even suicidal tendencies as the main symptoms. Depression usually induces or aggravates the development of other related diseases, such as sleep disorders and endocrine disorders. In today's society, the incidence of depression is increasing worldwide, and its pathogenesis is complex and generally believed to be related to genetic, psychological, environmental, and biological factors. Current studies have shown the key role of glial cells in the development of depression, and it is noteworthy that some recent evidence suggests that the development of depression may be closely related to viral infections, such as SARS-CoV-2, BoDV-1, ZIKV, HIV, and HHV6, which infect the organism and cause some degree of glial cells, such as astrocytes, oligodendrocytes, and microglia. This can affect the transmission of related proteins, neurotransmitters, and cytokines, which in turn leads to neuroinflammation and depression. Based on the close relationship between viruses and depression, this paper provides an in-depth analysis of the new mechanism of virus-induced depression, which is expected to provide a new perspective on the mechanism of depression and a new idea for the diagnosis of depression in the future.
抑郁症是一种常见的神经精神障碍，以长期反复发作的情绪低落、痛苦和绝望、悲观和焦虑，甚至自杀倾向为主要症状。抑郁症通常会诱发或加重其他相关疾病的发展，如睡眠障碍和内分泌紊乱。在当今社会，抑郁症的发病率在全球范围内呈上升趋势，其发病机制复杂，一般认为与遗传、心理、环境和生物因素有关。目前的研究表明，神经胶质细胞在抑郁症的发展中起着关键作用，值得注意的是，一些最近的证据表明，抑郁症的发展可能与病毒感染密切相关，如 SARS-CoV-2、BoDV-1、ZIKV、HIV 和 HHV6 等，这些病毒感染机体并导致一定程度的神经胶质细胞，如星形胶质细胞、少突胶质细胞和小胶质细胞。这会影响相关蛋白、神经递质和细胞因子的传递，进而导致神经炎症和抑郁症。基于病毒与抑郁症之间的密切关系，本文深入分析了病毒诱导抑郁症的新机制，有望为抑郁症的发病机制提供新的视角，为未来抑郁症的诊断提供新的思路。
