Calabrese Vittorio, Osakabe Naomi, Khan Foziya, Wenzel Uwe, Modafferi Sergio, Nicolosi Lidia, Fritsch Tilman, Jacob Ursula M, Abdelhameed Ali S, Rashan Luay
Department of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, 95125 Catania, Italy.
Department of Bioscience and Engineering, Shibaura Institute Technology, Tokyo, Japan.
Open Med (Wars). 2024 Jun 17;19(1):20240988. doi: 10.1515/med-2024-0988. eCollection 2024.
Parkinson's disease (PD), characterized by tremor, slowness of movement, stiffness, and poor balance, is due to a significant loss of dopaminergic neurons in the substantia nigra pars compacta and dopaminergic nerve terminals in the striatum with deficit of dopamine. To date the mechanisms sustaining PD pathogenesis are under investigation; however, a solid body of experimental evidence involves neuroinflammation, mitochondrial dysfunction, oxidative stress, and apoptotic cell death as the crucial factors operating in the pathogenesis of PD. Nutrition is known to modulate neuroinflammatory processes implicated in the pathogenesis and progression of this neurodegenerative disorder. Consistent with this notion, the Burseraceae family, which includes the genera and , are attracting emerging interest in the treatment of a wide range of pathological conditions, including neuroinflammation and cognitive decline. Bioactive components present in these species have been shown to improve cognitive function and to protect neurons from degeneration in , animal, as well as clinical research. These effects are mediated through the anti-inflammatory, antiamyloidogenic, anti-apoptotic, and antioxidative properties of bioactive components. Although many studies have exploited possible therapeutic approaches, data from human studies are lacking and their neuroprotective potential makes them a promising option for preventing and treating major neurodegenerative disorders.
帕金森病（PD）的特征为震颤、运动迟缓、僵硬和平衡能力差，是由于黑质致密部多巴胺能神经元以及纹状体中多巴胺能神经末梢大量丧失，导致多巴胺缺乏所致。迄今为止，维持帕金森病发病机制仍在研究中；然而，大量实验证据表明神经炎症、线粒体功能障碍、氧化应激和凋亡性细胞死亡是帕金森病发病机制中的关键因素。已知营养可调节与这种神经退行性疾病发病机制和进展相关的神经炎症过程。与此观点一致，包括[具体属名1]和[具体属名2]在内的橄榄科植物，在治疗包括神经炎症和认知衰退在内的多种病理状况方面正引起越来越多的关注。在[具体研究对象]、动物以及临床研究中，这些物种中存在的生物活性成分已被证明可改善认知功能并保护神经元免于退化。这些作用是通过生物活性成分的抗炎、抗淀粉样蛋白生成、抗凋亡和抗氧化特性介导的。尽管许多研究探索了可能的治疗方法，但缺乏人体研究数据，且它们的神经保护潜力使其成为预防和治疗主要神经退行性疾病的一个有前景的选择。
