Burrows G E
Am J Vet Res. 1979 Jul;40(7):991-8.
Certain physiologic and hematologic data were determined in ponies given Escherichia coli endotoxin by three routes: single IV dose, single intraperitoneal (IP) dose, and multiple IP boluses. In all ponies, the reaction was characterized by weakness, depression, peripheral circulatory abnormalities, and pyrexia. The pyrexia was more severe and was sustained in the ponies given multiple IP bolus endotoxin. Changes in packed cell volume, peripheral blood neutrophil, lymphocyte, and thrombocyte counts, and blood glucose were noticed in the three groups. Blood lactate and beta-glucuronidase values were determined and increases occurred only in the two IP endotoxin administration groups. A fibrinogen increase was observed in only the multiple IP bolus group. Attempts were made to correlate the lactate and beta-glucuronidase values with the severity and prognosis of the endotoxemia response. In general, the single IV bolus and, to a lesser extent, the single IP bolus endotoxin produced abrupt but transient responses. The multiple IP bolus endotoxin administration produced a more gradual and sustained response, which was more closely comparable with a clinical gastrointestinal disease problem than the other routes of administration produced.
通过三种途径给小马驹注射大肠杆菌内毒素后，测定了某些生理和血液学数据：单次静脉注射剂量、单次腹腔注射（IP）剂量以及多次腹腔注射大剂量。在所有小马驹中，反应的特征为虚弱、抑郁、外周循环异常和发热。多次腹腔注射大剂量内毒素的小马驹发热更严重且持续时间更长。三组均观察到红细胞压积、外周血中性粒细胞、淋巴细胞和血小板计数以及血糖的变化。测定了血乳酸和β-葡萄糖醛酸酶值，仅在两个腹腔注射内毒素给药组中出现升高。仅在多次腹腔注射大剂量组中观察到纤维蛋白原增加。试图将乳酸和β-葡萄糖醛酸酶值与内毒素血症反应的严重程度和预后相关联。一般来说，单次静脉注射大剂量以及在较小程度上单次腹腔注射大剂量内毒素会产生突然但短暂的反应。多次腹腔注射大剂量内毒素给药产生的反应更为渐进和持续，与临床胃肠疾病问题相比，比其他给药途径产生的反应更具可比性。
