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Strategic considerations on developing a CHIKV vaccine and ensuring equitable access for countries in need.关于研发基孔肯雅病毒疫苗及确保有需要国家公平获取疫苗的战略考量。
NPJ Vaccines. 2023 Aug 18;8(1):123. doi: 10.1038/s41541-023-00722-x.
2
Safety and immunogenicity of a single-shot live-attenuated chikungunya vaccine: a double-blind, multicentre, randomised, placebo-controlled, phase 3 trial.一种单次接种的减毒活寨卡病毒疫苗的安全性和免疫原性:一项双盲、多中心、随机、安慰剂对照、3 期临床试验。
Lancet. 2023 Jun 24;401(10394):2138-2147. doi: 10.1016/S0140-6736(23)00641-4. Epub 2023 Jun 12.
3
Analytical and Clinical Evaluation of a TaqMan Real-Time PCR Assay for the Detection of Chikungunya Virus.TaqMan 实时 PCR 法检测基孔肯雅病毒的分析和临床评估。
Microbiol Spectr. 2023 Aug 17;11(4):e0008823. doi: 10.1128/spectrum.00088-23. Epub 2023 Jun 5.
4
A phase 1, randomized, placebo-controlled, dose-ranging study to evaluate the safety and immunogenicity of an mRNA-based chikungunya virus vaccine in healthy adults.一项评估基于 mRNA 的基孔肯雅病毒疫苗在健康成年人中的安全性和免疫原性的 1 期、随机、安慰剂对照、剂量范围研究。
Vaccine. 2023 Jun 13;41(26):3898-3906. doi: 10.1016/j.vaccine.2023.04.064. Epub 2023 May 18.
5
Safety and immunogenicity of PXVX0317, an aluminium hydroxide-adjuvanted chikungunya virus-like particle vaccine: a randomised, double-blind, parallel-group, phase 2 trial.PXVX0317,一种含氢氧化铝佐剂的基孔肯雅病毒样颗粒疫苗的安全性和免疫原性:一项随机、双盲、平行组、2 期临床试验。
Lancet Infect Dis. 2022 Sep;22(9):1343-1355. doi: 10.1016/S1473-3099(22)00226-2. Epub 2022 Jun 13.
6
The global epidemiology of chikungunya from 1999 to 2020: A systematic literature review to inform the development and introduction of vaccines.1999 年至 2020 年全球基孔肯雅热流行病学:系统文献综述以提供疫苗开发和引入的信息。
PLoS Negl Trop Dis. 2022 Jan 12;16(1):e0010069. doi: 10.1371/journal.pntd.0010069. eCollection 2022 Jan.
7
A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus.一项针对脂质包裹的编码具有中和抗基孔肯雅病毒活性的单克隆抗体的 mRNA 的 1 期临床试验。
Nat Med. 2021 Dec;27(12):2224-2233. doi: 10.1038/s41591-021-01573-6. Epub 2021 Dec 9.
8
A single dose of ChAdOx1 Chik vaccine induces neutralizing antibodies against four chikungunya virus lineages in a phase 1 clinical trial.在一项 1 期临床试验中,单次接种 ChAdOx1 Chik 疫苗可诱导针对 4 种基孔肯雅病毒谱系的中和抗体。
Nat Commun. 2021 Jul 30;12(1):4636. doi: 10.1038/s41467-021-24906-y.
9
Chikungunya virus in Asia - Pacific: a systematic review.亚太地区的基孔肯雅热病毒:系统评价。
Emerg Microbes Infect. 2019;8(1):70-79. doi: 10.1080/22221751.2018.1559708.
10
Immunogenicity, safety, and tolerability of the measles-vectored chikungunya virus vaccine MV-CHIK: a double-blind, randomised, placebo-controlled and active-controlled phase 2 trial.基于麻疹病毒的基孔肯雅病毒疫苗 MV-CHIK 的免疫原性、安全性和耐受性:一项双盲、随机、安慰剂对照和阳性对照的 2 期临床试验。
Lancet. 2019 Dec 22;392(10165):2718-2727. doi: 10.1016/S0140-6736(18)32488-7. Epub 2018 Nov 5.

Advancements in chikungunya virus management: FDA approval of ixchiq vaccine and global perspectives.

作者信息

Irfan Hamza, Ahmed Aliza

机构信息

Department of Medicine Shaikh Khalifa Bin Zayed Al Nahyan Medical and Dental College Lahore Pakistan.

Department of Medicine Jinnah Sindh Medical University Karachi Pakistan.

出版信息

Health Sci Rep. 2024 Jun 21;7(6):e2183. doi: 10.1002/hsr2.2183. eCollection 2024 Jun.

DOI:10.1002/hsr2.2183
PMID:38912367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11192840/
Abstract
摘要