, a novel cancer/testis gene, regulates proliferation and apoptosis to promote progression of glioma.

To evaluate whether can serve as a diagnostic biomarker for glioma. We examined expression in multiple normal and glioma tissues. The diagnostic value of was evaluated using receiver operating characteristic curve analysis. The effect of ablation on proliferation, cell cycle and apoptosis was investigated. Database analyses were utilized for functional enrichment analysis. expression in normal tissue was restricted to the human testis. displayed significant diagnostic value in glioma. knockdown inhibited cell proliferation, induced apoptosis and resulted in induction of S-phase cell cycle arrest. Pathway enrichment analysis indicated that may participate in cancer. , a novel cancer/testis gene, may be a potential new diagnostic biomarker for glioma.