Liu Wanqing, Ma Dan, Cao Chuanlong, Liu Sai, Ma XinMao, Jia Fenglin, Li Pei, Zhang Hui, Liao Yi, Qu Haibo
Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Pediatr Res. 2024 Dec;96(7):1759-1764. doi: 10.1038/s41390-024-03359-1. Epub 2024 Jun 24.
Stuttering affects approximately 5% of children; however, its neurological basis remains unclear. Identifying imaging biomarkers could aid in early detection. Accordingly, we investigated resting-state cerebral blood flow (CBF) in children with developmental stuttering.
Pulsed arterial spin labelling magnetic resonance imaging was utilised to quantify CBF in 35 children with developmental stuttering and 27 healthy controls. We compared normalised CBF between the two groups and evaluated the correlation between abnormal CBF and clinical indicators.
Compared with healthy controls, the stuttering group exhibited decreased normalised CBF in the cerebellum lobule VI bilaterally, right cuneus, and left superior occipital gyrus and increased CBF in the right medial superior frontal gyrus, left rectus, and left dorsolateral superior frontal gyrus. Additionally, normalised CBF in the left cerebellum lobule VI and left superior occipital gyrus was positively correlated with stuttering severity.
Children who stutter display decreased normalised CBF primarily in the cerebellum and occipital gyrus, with increased normalised CBF in the frontal gyrus. Additionally, the abnormal CBF in the left cerebellum lobule VI and left superior occipital gyrus was associated with more severe symptoms, suggesting that decreased CBF in these areas may serve as a novel neuroimaging clue for stuttering.
Stuttering occurs in 5% of children and often extends into adulthood, which may negatively affect quality of life. Early detection and treatment are essential. We used pulsed arterial spin labelling magnetic resonance imaging to visualise the resting-state cerebral blood flow (CBF) in children who stutter and healthy children. Normalised CBF was decreased in stutterers in the cerebellum and occipital gyrus and increased in the frontal gyrus. Stuttering severity was linked to abnormal normalised CBF in the left cerebellum lobule VI and left superior occipital gyrus, suggesting that CBF may serve as a novel neuroimaging clue for stuttering.
口吃影响约5%的儿童；然而，其神经学基础仍不清楚。识别影像学生物标志物有助于早期检测。因此，我们研究了发育性口吃儿童的静息态脑血流量（CBF）。
采用脉冲动脉自旋标记磁共振成像技术对35名发育性口吃儿童和27名健康对照者的CBF进行量化。我们比较了两组之间的标准化CBF，并评估了异常CBF与临床指标之间的相关性。
与健康对照者相比，口吃组双侧小脑小叶VI、右侧楔叶和左侧枕上回的标准化CBF降低，右侧额上回内侧、左侧直肌和左侧额上回背外侧的CBF增加。此外，左侧小脑小叶VI和左侧枕上回的标准化CBF与口吃严重程度呈正相关。
口吃儿童主要在小脑和枕叶回表现出标准化CBF降低，而额叶回的标准化CBF增加。此外，左侧小脑小叶VI和左侧枕上回的CBF异常与更严重的症状相关，表明这些区域CBF降低可能是口吃的一种新的神经影像学线索。
5%的儿童会出现口吃，且常常持续到成年，这可能对生活质量产生负面影响。早期检测和治疗至关重要。我们使用脉冲动脉自旋标记磁共振成像技术来观察口吃儿童和健康儿童的静息态脑血流量（CBF）。口吃者小脑和枕叶回的标准化CBF降低，额叶回的标准化CBF增加。口吃严重程度与左侧小脑小叶VI和左侧枕上回的标准化CBF异常有关，表明CBF可能是口吃的一种新的神经影像学线索。
