Suppr超能文献

实验性心内膜炎：5-氟胞嘧啶对兔白色念珠菌感染的预防作用

Experimental endocarditis: prophylaxis of Candida albicans infections by 5-fluorocytosine in rabbits.

作者信息

Demierre G, Freedman L R

出版信息

Antimicrob Agents Chemother. 1979 Sep;16(3):252-4. doi: 10.1128/AAC.16.3.252.

DOI:10.1128/AAC.16.3.252
PMID:389156
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352840/
Abstract

The prevention of Candida endocarditis in the rabbit was easily accomplished with a single intramuscular injection of 75 mg of 5-FC (A predominantly fungistatic agent) per kg either 40 min before, or at the same time as, the intravenous challenge with Candida albicans. Renal infarcts were observed more often in rabbits with infected valvular vegetations than in control rabbits with sterile endocarditis. The prophylactic effect of 5-FC is greater in aortic vegetations than in the kidneys. This may be related to differences in the pathophysiology of infection and the pharmacokinetics of 5-FC in the two areas.

摘要

在兔子身上预防念珠菌性心内膜炎很容易实现，即在静脉注射白色念珠菌前40分钟或同时，每千克体重单次肌肉注射75毫克5-氟胞嘧啶（一种主要的抑菌剂）。与无菌性心内膜炎的对照兔子相比，感染性瓣膜赘生物的兔子中更常观察到肾梗死。5-氟胞嘧啶在主动脉赘生物中的预防效果比在肾脏中更大。这可能与两个区域感染的病理生理学差异以及5-氟胞嘧啶的药代动力学有关。

相似文献

1
Experimental endocarditis: prophylaxis of Candida albicans infections by 5-fluorocytosine in rabbits.实验性心内膜炎：5-氟胞嘧啶对兔白色念珠菌感染的预防作用
Antimicrob Agents Chemother. 1979 Sep;16(3):252-4. doi: 10.1128/AAC.16.3.252.
2
Efficacy of fluconazole in prophylaxis and treatment of experimental Candida endocarditis.氟康唑在实验性念珠菌性心内膜炎预防和治疗中的疗效。
Rev Infect Dis. 1990 Mar-Apr;12 Suppl 3:S294-8. doi: 10.1093/clinids/12.supplement_3.s294.
3
Experimental Candida albicans endocarditis: characterization of the disease and response to therapy.实验性白色念珠菌心内膜炎：疾病特征及对治疗的反应
Infect Immun. 1977 Jul;17(1):140-7. doi: 10.1128/iai.17.1.140-147.1977.
4
Efficacies of high-dose fluconazole plus amphotericin B and high-dose fluconazole plus 5-fluorocytosine versus amphotericin B, fluconazole, and 5-fluorocytosine monotherapies in treatment of experimental endocarditis, endophthalmitis, and pyelonephritis due to Candida albicans.高剂量氟康唑联合两性霉素B与高剂量氟康唑联合5-氟胞嘧啶对比两性霉素B、氟康唑及5-氟胞嘧啶单药疗法治疗白色念珠菌所致实验性心内膜炎、眼内炎和肾盂肾炎的疗效
Antimicrob Agents Chemother. 1999 Dec;43(12):2831-40. doi: 10.1128/AAC.43.12.2831.
5
Therapy of deep-seated fungal infections with 5-fluorocytosine.用5-氟胞嘧啶治疗深部真菌感染。
Aust N Z J Med. 1974 Oct;4(5):462-7. doi: 10.1111/j.1445-5994.1974.tb03218.x.
6
Comparison of fluconazole and amphotericin B in prophylaxis of experimental Candida endocarditis caused by non-C. albicans strains.氟康唑与两性霉素B预防非白色念珠菌菌株所致实验性念珠菌性心内膜炎的比较。
Antimicrob Agents Chemother. 1996 Feb;40(2):494-6. doi: 10.1128/AAC.40.2.494.
7
Experimental and clinical studies of 5-fluorocytosine activity in Candida ocular infections. I. In vitro activity of 5-fluorocytosine on Candida species isolated from ocular infections.
Chemotherapy. 1975;21(6):358-66. doi: 10.1159/000221880.
8
Experimental and clinical studies of 5-fluorocytosine activity in candida ocular infections, II. The effect of 5-fluorocytosine in treating experimental candida infection in rabbits' eyes.5-氟胞嘧啶在眼部念珠菌感染中活性的实验与临床研究，II. 5-氟胞嘧啶对兔眼实验性念珠菌感染的治疗作用
Infection. 1975;3(3):165-8. doi: 10.1007/BF01641341.
9
C. albicans resistance to 5-fluorocytosine.白色念珠菌对5-氟胞嘧啶的耐药性。
Br Med J. 1972 Aug 26;3(5825):531. doi: 10.1136/bmj.3.5825.531.
10
Experimental intravitreal 5-fluorocytosine.
Ann Ophthalmol. 1985 Jan;17(1):58-61.

引用本文的文献

1
Animal models: an important tool in mycology.动物模型：真菌学中的一项重要工具。
Med Mycol. 2007 Dec;45(8):657-84. doi: 10.1080/13693780701644140.
2
Chemotherapy of experimental endogenous Candida albicans endophthalmitis.实验性内源性白色念珠菌眼内炎的化疗
Trans Am Ophthalmol Soc. 1980;78:846-95.

本文引用的文献

1
Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart.实验性心内膜炎I. 因在兔心脏右侧放置聚乙烯导管而导致的葡萄球菌性心内膜炎。
Yale J Biol Med. 1970 Jun;42(6):394-410.
2
Treatment of disseminated candidiasis with 5-fluorocytosine.
J Infect Dis. 1974 Aug;130(2):155-9. doi: 10.1093/infdis/130.2.155.
3
Prosthetic valvular endocarditis. A 12-year review.人工瓣膜心内膜炎。一项为期12年的回顾。
Circulation. 1973 Jun;47(6):1319-26. doi: 10.1161/01.cir.47.6.1319.
4
Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens.实验性链球菌性心内膜炎的化疗。I. 常用推荐预防方案的比较。
J Clin Invest. 1973 Mar;52(3):592-8. doi: 10.1172/JCI107220.
5
Chemotherapy of experimental streptococcal endocarditis. 3. Failure of a bacteriostatic agent (tetracycline) in prophylaxis.实验性链球菌心内膜炎的化疗。3. 一种抑菌剂（四环素）预防失败。
J Clin Pathol. 1974 Apr;27(4):261-4. doi: 10.1136/jcp.27.4.261.
6
Postoperative fungal endocarditis. Fungemia, embolism, and therapy.术后真菌性心内膜炎。真菌血症、栓塞与治疗。
Arch Intern Med. 1974 Jul;134(1):116-20.
7
Prosthetic valve endocarditis. Analysis of 38 cases.人工瓣膜心内膜炎。38例分析。
Circulation. 1973 Aug;48(2):365-77. doi: 10.1161/01.cir.48.2.365.
8
Experimental endocarditis. IV. Tricuspid and aortic valve infection with Candida albicans in rabbits.实验性心内膜炎。IV. 兔白色念珠菌引起的三尖瓣和主动脉瓣感染
Yale J Biol Med. 1972 Apr;45(2):163-75.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验