The Key Laboratory of Industrial Biotechnology, School of Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
National Engineering Research Center of Cereal Fermentation, and Food Biomanufacturing, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu , 214122, China.
World J Microbiol Biotechnol. 2024 Jun 25;40(8):254. doi: 10.1007/s11274-024-04057-0.
Sesquiterpenes and tetraterpenes are classes of plant-derived natural products with antineoplastic effects. While plant extraction of the sesquiterpene, germacrene A, and the tetraterpene, lycopene suffers supply chain deficits and poor yields, chemical synthesis has difficulties in separating stereoisomers. This review highlights cutting-edge developments in producing germacrene A and lycopene from microbial cell factories. We then summarize the antineoplastic properties of β-elemene (a thermal product from germacrene A), sesquiterpene lactones (metabolic products from germacrene A), and lycopene. We also elaborate on strategies to optimize microbial-based germacrene A and lycopene production.
倍半萜烯和四萜烯是具有抗肿瘤作用的植物衍生天然产物的两个类别。虽然植物提取的倍半萜烯，大根香叶烯 A，和四萜烯，番茄红素，存在供应链短缺和产量低的问题，但化学合成在分离立体异构体方面存在困难。这篇综述重点介绍了从微生物细胞工厂生产大根香叶烯 A 和番茄红素的最新进展。然后，我们总结了 β-榄香烯（大根香叶烯 A 的热产物）、倍半萜烯内酯（大根香叶烯 A 的代谢产物）和番茄红素的抗肿瘤特性。我们还详细阐述了优化基于微生物的大根香叶烯 A 和番茄红素生产的策略。
