新生儿破伤风鞘内血清疗法：一项对照试验。

Intrathecal serotherapy in neonatal tetanus: a controlled trial.

作者信息

Sedaghatian M R

出版信息

Arch Dis Child. 1979 Aug;54(8):623-5. doi: 10.1136/adc.54.8.623.

DOI:10.1136/adc.54.8.623

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1545797/

Abstract

60 infants with neonatal tetanus were treated at random either by 40 000 units of equine tetanus antitoxin (TAT), intravenously and intramuscularly, or by 40 000 units TAT, IV and IM, plus 150 units of human tetanus immune globulin TIG) intrathecally. There were 30 infants in each treatment group. Babies were similar in age, sex, weight, incubation period, temperature, and signs and symptoms on arrival at the hospital. The mortality rate, days in hospital and days of sedation were not significantly different in the two groups.

摘要

60例新生儿破伤风患儿被随机分为两组进行治疗，一组静脉和肌肉注射40000单位马破伤风抗毒素（TAT），另一组静脉和肌肉注射40000单位TAT，同时鞘内注射150单位人破伤风免疫球蛋白（TIG）。每组各30例患儿。两组患儿在年龄、性别、体重、潜伏期、体温以及入院时的体征和症状方面相似。两组的死亡率、住院天数和镇静天数无显著差异。

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本文引用的文献

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Value of a large dose of antitoxin in clinical tetanus.

Lancet. 1960 Jul 30;2(7144):227-30. doi: 10.1016/s0140-6736(60)91425-2.

2

Role of tetanus antitoxin in the treatment of tetanus in children.破伤风抗毒素在儿童破伤风治疗中的作用。

J Pediatr. 1966 Feb;68(2):289-93. doi: 10.1016/s0022-3476(66)80160-9.

3

A new treatment for neonatal tetanus. Antitetanic serum and prednisolone given together intrathecally.新生儿破伤风的一种新疗法。鞘内联合注射抗破伤风血清和泼尼松龙。

Turk J Pediatr. 1967 Jul;9(3):89-95.

4

Tetanus neonatorum in Iran. Notes on etiology, manifestations and therapy.伊朗的新生儿破伤风。病因、临床表现及治疗要点

Clin Pediatr (Phila). 1970 Oct;9(10):609-10. doi: 10.1177/000992287000901014.

5

Intrathecal serotherapy of tetanus. I. Explanation of complications. II. Comparison of intrathecal tetanus immune globulin and tetanus antitoxin.破伤风的鞘内血清疗法。I. 并发症的解释。II. 鞘内注射破伤风免疫球蛋白与破伤风抗毒素的比较。

Turk J Pediatr. 1974 Jul;16(3):103-10.

6

Tetanus neonatorum in West Malaysia.马来西亚西部的新生儿破伤风。

J Trop Med Hyg. 1974 Sep;77(9):204-7.

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Double-blind trial of equine antitoxin and human immune globulin in tetanus neonatorum.马抗毒素和人免疫球蛋白用于新生儿破伤风的双盲试验。

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The fourth international conference on tetanus, Dakar, Sénégal, 1975.

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