鞘内注射抗破伤风血清（马源）联合类固醇治疗新生儿破伤风。
Intrathecal antitetanus serum (horse) with steroid in the treatment of neonatal tetanus.
作者信息
Singh A K, Bansal A, Goel S P, Agarwal V K
出版信息
Arch Dis Child. 1980 Jul;55(7):527-31. doi: 10.1136/adc.55.7.527.
107 patients with neonatal tetanus were studied and the value of intrathecal antitetanus serum with steroid was noted. The mortality rate in a control group (68%) was significantly higher than that of the test group (37%). Furthermore, a delay in antitetanus serum administration was found to have a strong positive linear correlation with the mortality rate. In fact, the mortality rate for neonates who were given antitetanus serum 24 hours after the onset of convulsions was found to be as high as for the control group. This suggests that intrathecal antitetanus serum is ineffective unless it is administered within 24 hours of the onset of convulsions. There was no significant difference in mortality rate whether a dose of 100 units or one of 50 units antitetanus serum was given intrathecally. The mean duration in hospital for survivals of the test group (7.4 days) was significantly shorter than that for survivals of the control group (10.4 days). No complication of intrathecal antitetanus serum was observed during the study.
对107例新生儿破伤风患者进行了研究，并观察了鞘内注射破伤风抗毒素联合类固醇的效果。对照组的死亡率（68%）显著高于试验组（37%）。此外，发现破伤风抗毒素给药延迟与死亡率呈强正线性相关。事实上，惊厥发作后24小时才给予破伤风抗毒素的新生儿死亡率与对照组一样高。这表明，除非在惊厥发作后24小时内给药，鞘内注射破伤风抗毒素无效。鞘内注射100单位或50单位破伤风抗毒素，死亡率无显著差异。试验组存活者的平均住院时间（7.4天）显著短于对照组存活者（10.4天）。研究期间未观察到鞘内注射破伤风抗毒素的并发症。
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