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新冠疫情对“生物衰老”的影响。

The impact of COVID-19 on "biological aging".

机构信息

College of Health and Life Sciences, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.

College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.

出版信息

Front Immunol. 2024 Jun 10;15:1399676. doi: 10.3389/fimmu.2024.1399676. eCollection 2024.

DOI:10.3389/fimmu.2024.1399676
PMID:38919619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11197383/
Abstract

The global impact of the SARS-CoV-2 pandemic has been unprecedented, posing a significant public health challenge. Chronological age has been identified as a key determinant for severe outcomes associated with SARS-CoV-2 infection. Epigenetic age acceleration has previously been observed in various diseases including human immunodeficiency virus (HIV), Cytomegalovirus (CMV), cardiovascular diseases, and cancer. However, a comprehensive review of this topic is still missing in the field. In this review, we explore and summarize the research work focusing on biological aging markers, i.e., epigenetic age and telomere attrition in COVID-19 patients. From the reviewed articles, we identified a consistent pattern of epigenetic age dysregulation and shortened telomere length, revealing the impact of COVID-19 on epigenetic aging and telomere attrition.

摘要

SARS-CoV-2 大流行的全球影响前所未有，对公共健康构成重大挑战。已确定年龄是与 SARS-CoV-2 感染相关的严重后果的关键决定因素。先前在各种疾病中观察到表观遗传年龄加速，包括人类免疫缺陷病毒 (HIV)、巨细胞病毒 (CMV)、心血管疾病和癌症。然而，该领域仍缺乏对这一主题的综合审查。在这篇综述中，我们探讨并总结了关注 COVID-19 患者生物衰老标志物（即表观遗传年龄和端粒磨损）的研究工作。从综述文章中，我们发现了表观遗传年龄失调和端粒缩短的一致模式，揭示了 COVID-19 对表观遗传衰老和端粒磨损的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfbf/11197383/1a2ff8961b78/fimmu-15-1399676-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfbf/11197383/1a2ff8961b78/fimmu-15-1399676-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfbf/11197383/1a2ff8961b78/fimmu-15-1399676-g001.jpg

相似文献

[1]
The impact of COVID-19 on "biological aging".

Front Immunol. 2024

[2]
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization.

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[3]
Epigenetic Clocks Are Not Accelerated in COVID-19 Patients.

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[4]
Accelerated biological aging in COVID-19 patients.

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[5]
Understanding the role of telomere attrition and epigenetic signatures in COVID-19 severity.

Gene. 2022-2-15

[6]
Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort.

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[7]
Signatures of epigenetic, biological and mitotic age acceleration and telomere shortening are associated with arsenic-induced skin lesions.

Arch Dermatol Res. 2024-5-22

[8]
Frailty is associated with the epigenetic clock but not with telomere length in a German cohort.

Clin Epigenetics. 2016-2-26

[9]
Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides-Baraitser syndrome.

Mol Genet Genomic Med. 2022-3

[10]
Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19.

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引用本文的文献

[1]
Non-Viral Therapy in COVID-19: Where Are We Standing? How Our Experience with COVID May Help Us Develop Cell Therapies for Long COVID Patients.

Biomedicines. 2025-7-23

[2]
Nucleotides as an Anti-Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study).

Adv Sci (Weinh). 2025-9

[3]
Long donor leukocyte telomeres raise risk of severe COVID-19 in recipients of allogeneic hematopoietic cell transplant.

Front Immunol. 2025-4-29

[4]
Associations of epigenetic aging and COVID- 19: A 3-year longitudinal study.

Geroscience. 2025-4-10

[5]
The COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives.

Geroscience. 2025-2

本文引用的文献

[1]
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization.

Clin Epigenetics. 2023-11-28

[2]
Persistent Pulmonary Fibrotic Sequelae in Patients With Telomere Shortening One Year After Severe COVID-19.

Arch Bronconeumol. 2024-1

[3]
Insights into aging from progeroid syndrome epigenetics.

Aging (Albany NY). 2023-8-5

[4]
Investigating the association of measures of epigenetic age with COVID-19 severity: evidence from secondary analyses of open access data.

Swiss Med Wkly. 2023-4-24

[5]
Biological age is increased by stress and restored upon recovery.

Cell Metab. 2023-5-2

[6]
Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada.

BMC Public Health. 2023-2-27

[7]
Role of epigenetics in the clinical evolution of COVID-19 disease. Epigenome-wide association study identifies markers of severe outcome.

Eur J Med Res. 2023-2-17

[8]
Accelerated epigenetic aging and DNA methylation alterations in Berardinelli-Seip congenital lipodystrophy.

Hum Mol Genet. 2023-5-18

[9]
Causal association of epigenetic aging and COVID-19 severity and susceptibility: A bidirectional Mendelian randomization study.

Front Med (Lausanne). 2022-9-23

[10]
Dimensions of childhood adversity differentially affect biological aging in major depression.

Transl Psychiatry. 2022-10-4

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