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From machine learning to clinical practice: phenotypic clusters of anti-MDA5 antibody-positive dermatomyositis.

作者信息

Koopman Jacob J E, Buhler Katherine A, Choi May Y

机构信息

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Rd, 6th Floor, Boston, MA 02115, USA.

Division of Rheumatology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N N14, Canada.

出版信息

Brief Bioinform. 2024 May 23;25(4). doi: 10.1093/bib/bbae303.

DOI:10.1093/bib/bbae303
PMID:38920344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11200185/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/11200185/ed358624896c/bbae303f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/11200185/ed358624896c/bbae303f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/11200185/ed358624896c/bbae303f1.jpg

相似文献

1
From machine learning to clinical practice: phenotypic clusters of anti-MDA5 antibody-positive dermatomyositis.从机器学习到临床实践：抗MDA5抗体阳性皮肌炎的表型聚类
Brief Bioinform. 2024 May 23;25(4). doi: 10.1093/bib/bbae303.
2
[Dermatomyositis associated with anti-MDA5 autoantibody].抗MDA5自身抗体相关的皮肌炎
Medicina (B Aires). 2018;78(5):360-363.
3
The clinical spectrum of dermatomyositis and the new autoantibodies - with regard to two clinical cases with distinct associations.皮肌炎的临床特征和新的自身抗体——基于两例具有明显关联的临床病例。
Australas J Dermatol. 2020 May;61(2):e241-e243. doi: 10.1111/ajd.13232. Epub 2019 Dec 27.
4
Differential clinical features of patients with clinically amyopathic dermatomyositis who have circulating anti-MDA5 autoantibodies with or without myositis-associated autoantibodies.伴或不伴肌炎相关自身抗体的临床无肌病性皮肌炎患者循环抗 MDA5 自身抗体的临床特征差异。
Respir Med. 2018 Jul;140:1-5. doi: 10.1016/j.rmed.2018.05.010. Epub 2018 May 22.
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Different phenotypes in dermatomyositis associated with anti-MDA5 antibody: Study of 121 cases.抗 MDA5 抗体相关皮肌炎的不同表型：121 例研究。
Neurology. 2020 Jul 7;95(1):e70-e78. doi: 10.1212/WNL.0000000000009727. Epub 2020 Jun 2.
6
Prognostic values of anti-Ro52 antibodies in anti-MDA5-positive clinically amyopathic dermatomyositis associated with interstitial lung disease.抗 MDA5 阳性伴间质性肺病的无肌病性皮肌炎中抗 Ro52 抗体的预后价值。
Rheumatology (Oxford). 2021 Jul 1;60(7):3343-3351. doi: 10.1093/rheumatology/keaa786.
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The relationship between type 1 IFN and vasculopathy in anti-MDA5 antibody-positive dermatomyositis patients.抗 MDA5 抗体阳性皮肌炎患者 1 型 IFN 与血管病变的关系。
Rheumatology (Oxford). 2019 May 1;58(5):786-791. doi: 10.1093/rheumatology/key386.
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Antimelanoma Differentiation-associated Gene 5 Antibody: Expanding the Clinical Spectrum in North American Patients with Dermatomyositis.抗黑色素瘤分化相关基因5抗体：拓展北美皮肌炎患者的临床谱
J Rheumatol. 2017 Mar;44(3):319-325. doi: 10.3899/jrheum.160682. Epub 2017 Jan 15.
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Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: A concise review with an emphasis on distinctive clinical features.抗黑色素瘤分化相关基因 5（MDA5）皮肌炎：简明综述，重点介绍独特的临床特征。
J Am Acad Dermatol. 2018 Apr;78(4):776-785. doi: 10.1016/j.jaad.2017.12.010. Epub 2017 Dec 9.
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Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease disguising as anti-synthetase syndrome.抗MDA5抗体阳性皮肌炎合并快速进展性间质性肺病，伪装成抗合成酶综合征。
Rheumatology (Oxford). 2021 Mar 2;60(3):e104-e106. doi: 10.1093/rheumatology/keaa507.

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ArXiv. 2025 May 14:arXiv:2505.09527v1.

本文引用的文献

1
Disease-associated immune cell endotypes in anti-MDA5-positive dermatomyositis using unbiased hierarchical clustering.采用无偏层次聚类分析抗 MDA5 阳性皮肌炎相关免疫细胞亚型。
Front Immunol. 2024 Mar 12;15:1349611. doi: 10.3389/fimmu.2024.1349611. eCollection 2024.
2
Rapidly progressive interstitial lung disease risk prediction in anti-MDA5 positive dermatomyositis: the CROSS model.抗 MDA5 阳性皮肌炎快速进展性间质性肺病风险预测：CROSS 模型。
Front Immunol. 2024 Feb 1;15:1286973. doi: 10.3389/fimmu.2024.1286973. eCollection 2024.
3
Disease patterns and specific trajectories of anti-MDA5-related disease: a multicentre retrospective study of 70 adult patients.
抗 MDA5 相关疾病的疾病模式和特定轨迹：70 名成年患者的多中心回顾性研究。
Front Immunol. 2024 Jan 8;14:1319957. doi: 10.3389/fimmu.2023.1319957. eCollection 2023.
4
From data to diagnosis: how machine learning is revolutionizing biomarker discovery in idiopathic inflammatory myopathies.从数据到诊断：机器学习如何彻底改变特发性炎性肌病的生物标志物发现。
Brief Bioinform. 2023 Nov 22;25(1). doi: 10.1093/bib/bbad514.
5
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress.抗 MDA5 抗体阳性皮肌炎：发病机制与临床进展。
Nat Rev Rheumatol. 2024 Jan;20(1):48-62. doi: 10.1038/s41584-023-01054-9. Epub 2023 Dec 6.
6
Peripheral lymphocyte count defines the clinical phenotypes and prognosis in patients with anti-MDA5-positive dermatomyositis.外周血淋巴细胞计数可明确抗MDA5阳性皮肌炎患者的临床表型及预后。
J Intern Med. 2023 Apr;293(4):494-507. doi: 10.1111/joim.13607. Epub 2023 Feb 2.
7
Identification of Three Different Phenotypes in Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Positive Dermatomyositis Patients: Implications for Prediction of Rapidly Progressive Interstitial Lung Disease.鉴定抗黑色素瘤分化相关基因 5 抗体阳性皮肌炎患者的三种不同表型：对快速进展性间质性肺病预测的影响。
Arthritis Rheumatol. 2023 Apr;75(4):609-619. doi: 10.1002/art.42308. Epub 2023 Mar 17.
8
Anti-melanoma differentiation-associated 5 gene antibody-positive dermatomyositis exhibit three clinical phenotypes with different prognoses.抗黑色素瘤分化相关蛋白 5 基因抗体阳性皮肌炎具有三种不同预后的临床表型。
Clin Exp Rheumatol. 2022 Feb;40(2):304-308. doi: 10.55563/clinexprheumatol/df2oc3. Epub 2022 Jan 14.
9
Different phenotypes in dermatomyositis associated with anti-MDA5 antibody: Study of 121 cases.抗 MDA5 抗体相关皮肌炎的不同表型：121 例研究。
Neurology. 2020 Jul 7;95(1):e70-e78. doi: 10.1212/WNL.0000000000009727. Epub 2020 Jun 2.