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纳米结构材料在口腔软组织和骨组织再生中的适用性——综述

The Applicability of Nanostructured Materials in Regenerating Soft and Bone Tissue in the Oral Cavity-A Review.

作者信息

Muresan Giorgiana Corina, Boca Sanda, Lucaciu Ondine, Hedesiu Mihaela

机构信息

Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

Interdisciplinary Research Institute in Bio-Nano-Sciences, Babes-Bolyai University, 400271 Cluj-Napoca, Romania.

出版信息

Biomimetics (Basel). 2024 Jun 8;9(6):348. doi: 10.3390/biomimetics9060348.

Abstract

BACKGROUND AND OBJECTIVES

Two of the most exciting new technologies are biotechnology and nanotechnology. The science of nanostructures, or nanotechnology, is concerned with the development, testing, and use of structures and molecules with nanoscale dimensions ranging from 1 to 100 nm. The development of materials and tools with high specificity that interact directly at the subcellular level is what makes nanotechnology valuable in the medical sciences. At the cellular or tissue level, this might be converted into focused clinical applications with the greatest possible therapeutic benefits and the fewest possible side effects. The purpose of the present study was to review the literature and explore the applicability of the nanostructured materials in the process of the regeneration of the soft and hard tissues of the oral cavity.

MATERIALS AND METHODS

An electronic search of articles was conducted in several databases, such as PubMed, Embase, and Web of Science, to conduct this study, and the 183 articles that were discovered were chosen and examined, and only 22 articles met the inclusion criteria in this review.

RESULTS

The findings of this study demonstrate that using nanoparticles can improve the mechanical properties, biocompatibility, and osteoinductivity of biomaterials.

CONCLUSIONS

Most recently, breakthroughs in tissue engineering and nanotechnology have led to significant advancements in the design and production of bone graft substitutes and hold tremendous promise for the treatment of bone abnormalities. The creation of intelligent nanostructured materials is essential for various applications and therapies, as it allows for the precise and long-term delivery of medication, which yields better results.

摘要

背景与目的

两项最令人兴奋的新技术是生物技术和纳米技术。纳米结构科学,即纳米技术,涉及开发、测试和使用尺寸在1至100纳米范围内的纳米级结构和分子。开发具有高特异性且能在亚细胞水平直接相互作用的材料和工具,这使得纳米技术在医学领域具有重要价值。在细胞或组织层面,这可能会转化为具有最大治疗益处和最少副作用的针对性临床应用。本研究的目的是回顾文献,探讨纳米结构材料在口腔软硬组织再生过程中的适用性。

材料与方法

为开展本研究,在多个数据库(如PubMed、Embase和科学网)中对文章进行了电子检索,共筛选出183篇文章并进行检查,本综述中仅有22篇文章符合纳入标准。

结果

本研究结果表明,使用纳米颗粒可改善生物材料的力学性能、生物相容性和骨诱导性。

结论

最近,组织工程和纳米技术的突破在骨移植替代物的设计和生产方面取得了重大进展,对治疗骨异常具有巨大潜力。创建智能纳米结构材料对于各种应用和治疗至关重要,因为它能够实现药物的精确和长期递送,从而产生更好的效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3d6/11201588/b375e0308b2e/biomimetics-09-00348-g001.jpg

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