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用于药物递送和组织工程应用的纳米结构材料。

Nanostructured Materials for Drug Delivery and Tissue Engineering Applications.

作者信息

Matić Antonela, Sher Emina Karahmet, Farhat Esma Karahmet, Sher Farooq

机构信息

Faculty of Pharmacy, University of Modern Sciences - CKM, Mostar, 88000, Bosnia and Herzegovina.

Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.

出版信息

Mol Biotechnol. 2023 Jun 22. doi: 10.1007/s12033-023-00784-1.

Abstract

Nanotechnology and nanostructured materials for drug delivery and tissue engineering applications are relatively new field that is constantly advancing and expanding. The materials used are at the nanoscale level. Recently, great discoveries and applications have been made (Agents for use in chemotherapy, biological agents and immunotherapy agents) in the treatment of diseases in various areas. Tissue engineering is based on the regeneration and repair of damaged organs and tissues by developing biological substitutes that restore, maintain or improve the function of tissues and organs. Cells isolated from patients are used to seed 3D nanoparticles that can be synthetic or natural biomaterials. For the development of new tissue in tissue engineering, it is necessary to meet the conditions for connecting cells. This paper will present the ways of connecting cells and creating new tissues. Some recent discoveries and advances in the field of nanomedicine and the application of nanotechnology in drug delivery will be presented. Furthermore, the improvement of the effectiveness of new and old drugs based on the application of nanotechnology will be shown.

摘要

用于药物递送和组织工程应用的纳米技术和纳米结构材料是一个相对较新的领域,并且在不断进步和扩展。所使用的材料处于纳米尺度水平。最近,在各个领域的疾病治疗方面已经取得了重大发现和应用(用于化疗的药物、生物制剂和免疫治疗剂)。组织工程基于通过开发能够恢复、维持或改善组织和器官功能的生物替代物来实现受损器官和组织的再生与修复。从患者体内分离出的细胞被用于接种三维纳米颗粒,这些纳米颗粒可以是合成的或天然的生物材料。对于组织工程中新组织的发育而言,满足细胞连接的条件是必要的。本文将介绍细胞连接和创建新组织的方法。还将介绍纳米医学领域的一些最新发现和进展以及纳米技术在药物递送中的应用。此外,还将展示基于纳米技术应用对新旧药物有效性的改善。

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