Department of Endodontics, Hospital of Stomatology, Jilin University, Changchun 130000, China.
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130000, China.
Molecules. 2022 Jun 17;27(12):3881. doi: 10.3390/molecules27123881.
Breakthroughs in the field of nanotechnology, especially in nanochemistry and nanofabrication technologies, have been attracting much attention, and various nanomaterials have recently been developed for biomedical applications. Among these nanomaterials, nanoscale titanium dioxide (nano-TiO) has been widely valued in stomatology due to the fact of its excellent biocompatibility, antibacterial activity, and photocatalytic activity as well as its potential use for applications such as dental implant surface modification, tissue engineering and regenerative medicine, drug delivery carrier, dental material additives, and oral tumor diagnosis and treatment. However, the biosafety of nano-TiO is controversial and has become a key constraint in the development of nano-TiO applications in stomatology. Therefore, in this review, we summarize recent research regarding the applications of nano-TiO in stomatology, with an emphasis on its performance characteristics in different fields, and evaluations of the biological security of nano-TiO applications. In addition, we discuss the challenges, prospects, and future research directions regarding applications of nano-TiO in stomatology that are significant and worthy of further exploration.
纳米技术领域的突破，特别是在纳米化学和纳米制造技术方面，引起了广泛关注，最近已经开发出各种用于生物医学应用的纳米材料。在这些纳米材料中，由于纳米二氧化钛（nano-TiO）具有优异的生物相容性、抗菌活性和光催化活性，以及在牙科植入物表面改性、组织工程和再生医学、药物输送载体、牙科材料添加剂和口腔肿瘤诊断和治疗等方面的潜在应用，因此在口腔医学中得到了广泛的重视。然而，nano-TiO 的生物安全性存在争议，这已成为限制其在口腔医学中应用发展的关键因素。因此，在本文综述中，我们总结了 nano-TiO 在口腔医学中的应用研究进展，重点介绍了其在不同领域的性能特点以及对 nano-TiO 应用的生物安全性评价。此外，我们还讨论了 nano-TiO 在口腔医学应用中面临的挑战、前景和未来研究方向，这些问题具有重要意义，值得进一步探索。
