Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Center for Single-Cell Omics and Tumor Liquid Biopsy, Zhongnan Hospital of Wuhan University, Wuhan, China.
JPEN J Parenter Enteral Nutr. 2024 Aug;48(6):735-745. doi: 10.1002/jpen.2661. Epub 2024 Jun 23.
Oxidative stress has been implicated in the pathogenesis and progression of dyslipidemia. We aimed to investigate the association between the oxidative balance score, and dyslipidemia, as well as to assess the mortality risk associated with oxidative balance score in patients with dyslipidemia.
We performed a mortality follow-up study of a cross-sectional cohort of 26,118 adults from the National Health and Nutrition Examination Survey 1999-2018. The total oxidative balance score was calculated by 16 dietary nutrients (dietary oxidative balance score) and four lifestyle factors (lifestyle oxidative balance score). Weighted Cox proportional hazard model was applied to determine the relationship between oxidative balance score and all-cause or cardiovascular disease (CVD) mortality within the dyslipidemia group.
During a median follow-up of 118 months, 2448 all-cause deaths (766 CVD-related) occurred. A significant negative correlation was observed between total oxidative balance score, dietary oxidative balance score, lifestyle oxidative balance score, and dyslipidemia. The multivariable-adjusted odds ratios and 95% CIs for dyslipidemia were 0.86 (0.77-0.97), 0.80 (0.72-0.91), and 0.63 (0.56-0.70), respectively, when comparing the second, third, and fourth quartiles of total oxidative balance score to the reference lowest quartile (P for trend <0.0001). Increasing total oxidative balance score was inversely associated with all-cause (hazard ratio [HR] = 0.98, 95% CI 0.98-0.99) and CVD-specific mortality (HR = 0.98, 95% CI 0.97-0.99) in participants with dyslipidemia.
Oxidative balance score is inversely associated with dyslipidemia and linked to all-cause and CVD-related mortality, highlighting the potentially protective role of an antioxidant-rich diet against dyslipidemia.
氧化应激与血脂异常的发病机制和进展有关。我们旨在研究氧化平衡评分与血脂异常的关系，并评估氧化平衡评分与血脂异常患者死亡率的相关性。
我们对 1999 年至 2018 年国家健康和营养调查的 26118 名成年人进行了死亡率随访研究。通过 16 种膳食营养素（膳食氧化平衡评分）和 4 种生活方式因素（生活方式氧化平衡评分）计算总氧化平衡评分。应用加权 Cox 比例风险模型确定血脂异常组中氧化平衡评分与全因或心血管疾病（CVD）死亡率之间的关系。
在中位随访 118 个月期间，发生了 2448 例全因死亡（766 例与 CVD 相关）。总氧化平衡评分、膳食氧化平衡评分、生活方式氧化平衡评分与血脂异常呈显著负相关。多变量调整后的血脂异常比值比（OR）和 95%置信区间（CI）分别为 0.86（0.77-0.97）、0.80（0.72-0.91）和 0.63（0.56-0.70），当将总氧化平衡评分的第二、三、四分位与最低参考四分位进行比较时（P<0.0001）。总氧化平衡评分的增加与血脂异常患者的全因（危险比[HR] = 0.98，95%CI 0.98-0.99）和 CVD 特异性死亡率（HR = 0.98，95%CI 0.97-0.99）呈负相关。
氧化平衡评分与血脂异常呈负相关，与全因和 CVD 相关死亡率相关，这突显了富含抗氧化剂的饮食对血脂异常的潜在保护作用。
