美国中老年人群氧化平衡评分与代谢综合征及其组分的关联
Association of oxidative balance score with metabolic syndrome and its components in middle-aged and older individuals in the United States.
作者信息
Zhang Qu, Wu Yemei, Luo Bo
机构信息
Department of Radiotherapy Center, Breast Cancer Center, National Key Clinical Specialty Construction Discipline, Hubei Provincial Clinical Research Center for Breast Cancer, Wuhan Clinical Research Center for Breast Cancer, Tongji Medical College, Hubei Cancer Hospital, Huazhong University of Science and Technology, Wuhan, China.
Tongji Medical College, Hubei Cancer Hospital, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Front Nutr. 2025 Feb 6;12:1523791. doi: 10.3389/fnut.2025.1523791. eCollection 2025.
BACKGROUND
The prevalence of metabolic syndrome (MetS) among middle-aged and older individuals in the U.S. is rising, posing significant mortality risks. Diet is a key factor in MetS development, yet few studies have examined the combined effects of dietary and lifestyle factors on MetS in this group. Recently, the oxidative balance score (OBS), an indicator of oxidative status encompassing diet and physical activity, has attracted interest. This study explores the association between OBS and MetS, as well as its individual components, in middle-aged and older Americans.
METHODS
Data from 6,157 participants aged 45 years and older in the National Health and Nutrition Examination Survey (NHANES) (1999-2018) were analyzed. The OBS was calculated using 16 dietary and four lifestyle factors. Logistic regression was used to assess associations between OBS and MetS. Separate analyses examined dietary OBS (DOBS) and lifestyle OBS (LOBS) in relation to MetS.
RESULTS
Higher OBS quartiles were associated with a reduced MetS risk (OR 0.25; 95% confidence interval [CI]: 0.12-0.51; < 0.0001), after adjusting for confounders. Increased OBS was linked to decreases in waist circumference (WC) (OR 0.41; 95% CI: 0.30-0.51; < 0.0001), triglycerides (TG) (OR 0.71; 95% CI: 0.53-0.92; = 0.0139), blood pressure (BP) (OR 0.53; 95% CI: 0.40-0.69; < 0.0001), and fasting glucose (FG) (OR 0.61; 95% CI: 0.45-0.81; < 0.0001), while HDL-C increased (OR 0.68; 95% CI: 0.51-0.90; = 0.0065). DOBS was inversely associated with MetS through reductions in BP and FG and increased HDL-C, though it showed no significant effect on WC or TG. LOBS was associated with reductions across WC, BP, FG, TG, and an increase in HDL-C.
CONCLUSION
OBS is inversely associated with MetS in middle-aged and older U.S. adults. Enhancing OBS through dietary guidelines emphasizing antioxidant-rich foods, fiber, and unsaturated fats, alongside lifestyle changes like regular exercise, smoking cessation, and moderate alcohol intake, may be crucial in MetS prevention for this population.
背景
美国中老年人群中代谢综合征（MetS）的患病率正在上升，带来了重大的死亡风险。饮食是MetS发展的关键因素，但很少有研究探讨饮食和生活方式因素对该群体MetS的综合影响。最近，氧化平衡评分（OBS）作为一种涵盖饮食和身体活动的氧化状态指标，引起了人们的关注。本研究探讨了美国中老年人中OBS与MetS及其各个组成部分之间的关联。
方法
分析了美国国家健康与营养检查调查（NHANES）（1999 - 2018年）中6157名年龄在45岁及以上参与者的数据。OBS通过16种饮食和4种生活方式因素计算得出。采用逻辑回归评估OBS与MetS之间的关联。分别分析了饮食OBS（DOBS）和生活方式OBS（LOBS）与MetS的关系。
结果
在调整混杂因素后，较高的OBS四分位数与MetS风险降低相关（比值比[OR]0.25；95%置信区间[CI]：0.12 - 0.51；P < 0.0001）。OBS升高与腰围（WC）降低（OR 0.41；95% CI：0.30 - 0.51；P < 0.0001）、甘油三酯（TG）降低（OR 0.71；95% CI：0.53 - 0.92；P = 0.0139）、血压（BP）降低（OR 0.53；95% CI：0.40 - 0.69；P < 0.0001）和空腹血糖（FG）降低（OR 0.61；95% CI：0.45 - 0.81；P < 0.0001）相关，而高密度脂蛋白胆固醇（HDL - C）升高（OR 0.68；95% CI：0.51 - 0.90；P = 0.0065）。DOBS通过降低BP和FG以及增加HDL - C与MetS呈负相关，尽管对WC或TG没有显著影响。LOBS与WC、BP、FG、TG降低以及HDL - C升高相关。
结论
在美国中老年成年人中，OBS与MetS呈负相关。通过强调富含抗氧化剂的食物、纤维和不饱和脂肪的饮食指南，以及如定期锻炼、戒烟和适度饮酒等生活方式的改变来提高OBS，可能对该人群预防MetS至关重要。
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