Skin-CAD: Explainable deep learning classification of skin cancer from dermoscopic images by feature selection of dual high-level CNNs features and transfer learning.

Skin cancer (SC) significantly impacts many individuals' health all over the globe. Hence, it is imperative to promptly identify and diagnose such conditions at their earliest stages using dermoscopic imaging. Computer-aided diagnosis (CAD) methods relying on deep learning techniques especially convolutional neural networks (CNN) can effectively address this issue with outstanding outcomes. Nevertheless, such black box methodologies lead to a deficiency in confidence as dermatologists are incapable of comprehending and verifying the predictions that were made by these models. This article presents an advanced an explainable artificial intelligence (XAI) based CAD system named "Skin-CAD" which is utilized for the classification of dermoscopic photographs of SC. The system accurately categorises the photographs into two categories: benign or malignant, and further classifies them into seven subclasses of SC. Skin-CAD employs four CNNs of different topologies and deep layers. It gathers features out of a pair of deep layers of every CNN, particularly the final pooling and fully connected layers, rather than merely depending on attributes from a single deep layer. Skin-CAD applies the principal component analysis (PCA) dimensionality reduction approach to minimise the dimensions of pooling layer features. This also reduces the complexity of the training procedure compared to using deep features from a CNN that has a substantial size. Furthermore, it combines the reduced pooling features with the fully connected features of each CNN. Additionally, Skin-CAD integrates the dual-layer features of the four CNNs instead of entirely depending on the features of a single CNN architecture. In the end, it utilizes a feature selection step to determine the most important deep attributes. This helps to decrease the general size of the feature set and streamline the classification process. Predictions are analysed in more depth using the local interpretable model-agnostic explanations (LIME) approach. This method is used to create visual interpretations that align with an already existing viewpoint and adhere to recommended standards for general clarifications. Two benchmark datasets are employed to validate the efficiency of Skin-CAD which are the Skin Cancer: Malignant vs. Benign and HAM10000 datasets. The maximum accuracy achieved using Skin-CAD is 97.2 % and 96.5 % for the Skin Cancer: Malignant vs. Benign and HAM10000 datasets respectively. The findings of Skin-CAD demonstrate its potential to assist professional dermatologists in detecting and classifying SC precisely and quickly.