Cujbă Larisa, Banc Ana, Drugan Tudor, Coadă Camelia Alexandra, Cristea Andreea-Petra, Stan Cristina, Nicula Cristina
Medical Doctoral School, University of Oradea, 410087 Oradea, Romania.
Department of Ophthalmology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Diagnostics (Basel). 2024 Jun 14;14(12):1255. doi: 10.3390/diagnostics14121255.
Retrograde axonal neurodegeneration along the visual pathway-either direct or trans-synaptic-has already been demonstrated in multiple sclerosis (MS), as well as in compressive, vascular, or posttraumatic lesions of the visual pathway. Optical coherence tomography (OCT) can noninvasively track macular and optic nerve changes occurring as a result of this phenomenon. Our paper aimed to review the existing literature regarding hemimacular atrophic changes in the ganglion cell layer identified using OCT examination in MS patients without prior history of optic neuritis. Homonymous hemimacular atrophy has been described in post-chiasmal MS lesions, even in patients with normal visual field results. Temporal and nasal macular OCT evaluation should be performed separately in all MS patients, in addition to an optic nerve OCT evaluation and a visual field exam.
沿视觉通路的逆行性轴突神经变性——无论是直接的还是跨突触的——已在多发性硬化症（MS）以及视觉通路的压迫性、血管性或创伤后病变中得到证实。光学相干断层扫描（OCT）可以无创地追踪由此现象导致的黄斑和视神经变化。我们的论文旨在回顾现有文献，这些文献涉及在无视神经炎病史的MS患者中通过OCT检查发现的神经节细胞层半黄斑萎缩性变化。即使在视野结果正常的患者中，视交叉后MS病变中也已描述了同侧半黄斑萎缩。除了视神经OCT评估和视野检查外，所有MS患者都应分别进行颞侧和鼻侧黄斑OCT评估。
