Mindubayeva Farida, Akhmaltdinova Lyudmila, Ospanova Mariya, Tukbekova Bibigul, Bolatbekuly Zhanat, Niyazova Yuliya, Salikhova Yelena, Avdienko Olga, Akhmetova Meruert
Department of Physiology, NCJSC «Karaganda Medical University», Karaganda 100000, Kazakhstan.
Scientific Research Laboratory, NCJSC «Karaganda Medical University», Karaganda 100000, Kazakhstan.
Children (Basel). 2024 Jun 17;11(6):737. doi: 10.3390/children11060737.
This study assesses the utility of early biomarkers-5-hydroxyindoleacetic acid (5-HIAA) and insulin-like growth factor 1 (IGF-1)-for diagnosing and monitoring pulmonary hypertension (PH) in children with congenital heart defects (CHD). Due to the risks associated with invasive diagnostics, such as right heart catheterization, non-invasive biomarkers provide a safer alternative for early PH detection. This cohort-based study utilized blood and urine samples to measure 5-HIAA and IGF-1 levels via enzyme immunoassays. Our findings revealed significant changes in 5-HIAA concentrations across various biological matrices, supporting its potential as a diagnostic tool. Specifically, altered levels in urine and plasma reflect its role in serotonin metabolism and vascular remodeling in PH. IGF-1 levels were notably reduced in plasma, suggesting its involvement in PH pathophysiology. ROC analysis confirmed the diagnostic efficacy of these biomarkers, particularly 5-HIAA's high specificity and sensitivity. In conclusion, 5-HIAA and IGF-1 levels correlate well with PH, underscoring their diagnostic value for early PH detection in children with CHD.
本研究评估了早期生物标志物——5-羟吲哚乙酸（5-HIAA）和胰岛素样生长因子1（IGF-1）在诊断和监测先天性心脏病（CHD）患儿肺动脉高压（PH）方面的效用。由于诸如右心导管插入术等侵入性诊断存在风险，非侵入性生物标志物为早期PH检测提供了更安全的替代方法。这项基于队列的研究利用血液和尿液样本，通过酶免疫测定法测量5-HIAA和IGF-1水平。我们的研究结果显示，5-HIAA浓度在各种生物基质中存在显著变化，支持其作为诊断工具的潜力。具体而言，尿液和血浆中水平的改变反映了其在PH中血清素代谢和血管重塑中的作用。血浆中IGF-1水平显著降低，表明其参与了PH的病理生理学过程。ROC分析证实了这些生物标志物的诊断效力，特别是5-HIAA的高特异性和敏感性。总之，5-HIAA和IGF-1水平与PH密切相关，突出了它们在CHD患儿早期PH检测中的诊断价值。
