Zulfiqar Abrar-Ahmad, Andres Emmanuel
Internal Medicine Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.
J Clin Med. 2024 Jun 14;13(12):3481. doi: 10.3390/jcm13123481.
The primary aim of the study was to validate the Zulfiqar Frailty Scale (ZFS) and examine its concordance with the modified Short Emergency Geriatric Assessment (mSEGA) scale, Part A.
A prospective observational study was conducted in Guadeloupe (France) over a two-month duration (from 20 February to 20 April 2024), involving elderly individuals aged 65 and older, deemed self-sufficient with an ADL (Activities of Daily Living) score exceeding four out of six.
Within this community cohort of 98 individuals, averaging 75 years in age, frailty according to the modified SEGA criteria was prevalent in 29%. Frailty according to the "ZFS" score was prevalent in 40%. Key predictors of frailty identified in our study included age, comorbidity (Charlson score), polypharmacy (total number of medications and therapeutic classes), and functional ability (ADL scores). Notably, experiences of falls and hospitalizations within the past six months significantly influenced the classification of frailty according to both ZFS and SEGA scales. Significant associations with the presence of home care aides ( < 0.0001), monopodal support test results ( < 0.0001), memory impairments ( < 0.0001), and recent hospitalizations ( = 0.0054) underscored the multidimensional impact of frailty. The Pearson correlation coefficient and its 95% confidence interval between the SEGA and Zulfiqar Frailty Scales stood at 0.73 [0.61: 0.81]. The discernment threshold for frailty was set at three out of six criteria, showcasing a sensitivity of 64% and a negative predictive value of 80%. The area under the curve (AUC) for the Zulfiqar Frailty Scale was reported as 0.8.
The "ZFS" tool allows for the detection of frailty with a highly satisfactory sensitivity and negative predictive value.
本研究的主要目的是验证祖尔菲卡尔衰弱量表(ZFS),并检验其与改良的简易急诊老年评估(mSEGA)量表A部分的一致性。
在瓜德罗普岛(法国)进行了一项为期两个月(从2024年2月20日至4月20日)的前瞻性观察研究,纳入65岁及以上的老年人,这些老年人被认为生活自理,日常生活活动(ADL)评分在六项中超过四项。
在这个由98人组成的社区队列中,平均年龄为75岁,根据改良的SEGA标准,衰弱患病率为29%。根据“ZFS”评分,衰弱患病率为40%。我们的研究中确定的衰弱关键预测因素包括年龄、合并症(查尔森评分)、多重用药(药物总数和治疗类别)和功能能力(ADL评分)。值得注意的是,过去六个月内的跌倒和住院经历对ZFS和SEGA量表的衰弱分类有显著影响。与家庭护理人员的存在(<0.0001)、单足支撑测试结果(<0.0001)、记忆障碍(<0.0001)和近期住院(=0.0054)的显著关联突出了衰弱的多维度影响。SEGA量表和祖尔菲卡尔衰弱量表之间的皮尔逊相关系数及其95%置信区间为0.73 [0.61: 0.81]。衰弱的辨别阈值设定为六项标准中的三项,敏感性为64%,阴性预测值为80%。祖尔菲卡尔衰弱量表的曲线下面积(AUC)报告为0.8。
“ZFS”工具能够以非常令人满意的敏感性和阴性预测值检测衰弱。