State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, School of Life Sciences, Xiamen University, Xiamen 361102, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Collaborative Innovation Center of Biologic Products, National Innovation Platform for Industry-Education Integration in Vaccine Research, The Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical Sciences, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen 361102, China.
Viruses. 2024 Jun 1;16(6):900. doi: 10.3390/v16060900.
Currently, SARS-CoV-2 has evolved into various variants, including the numerous highly mutated Omicron sub-lineages, significantly increasing immune evasion ability. The development raises concerns about the possibly diminished effectiveness of available vaccines and antibody-based therapeutics. Here, we describe those representative categories of broadly neutralizing antibodies (bnAbs) that retain prominent effectiveness against emerging variants including Omicron sub-lineages. The molecular characteristics, epitope conservation, and resistance mechanisms of these antibodies are further detailed, aiming to offer suggestion or direction for the development of therapeutic antibodies, and facilitate the design of vaccines with broad-spectrum potential.
目前，SARS-CoV-2 已经进化出多种变体，包括具有高度突变性的奥密克戎亚谱系，显著提高了免疫逃逸能力。这一发展引发了人们对现有疫苗和基于抗体的治疗药物可能效果降低的担忧。在这里，我们描述了那些对包括奥密克戎亚谱系在内的新兴变体仍然保持显著有效性的代表性广谱中和抗体（bnAbs）类别。进一步详细描述了这些抗体的分子特征、表位保守性和耐药机制，旨在为治疗性抗体的开发提供建议或方向，并有助于设计具有广谱潜力的疫苗。
