Negrini A C, Troise C, Voltolini S, Siccardi M, Grassia L
Ann Allergy. 1985 Jun;54(6):534-7.
Ninety atopic patients with allergic asthma and/or rhinitis were classified into three groups: group A, consisting of 30 patients never subjected to immunotherapy; group B, 30 patients receiving immunotherapy for various allergies for 3 to 24 months; group C, 30 patients receiving immunotherapy for 5 or more years. The following studies were performed using standard techniques: quantitative determination of serum immunoglobulin concentrations IgA, IgG, IgM, rheumatoid factor, C3 and C4 concentrations, antinuclear antibodies (ANA). Circulating immune complexes were detected by a competitive immuno-enzyme assay. No statistical differences were found in the groups studied for every parameter considered. Although signs and symptoms of autoimmune disease were not present, an elevated incidence of ANA in the entire group (23.3%) was found.
90名患有过敏性哮喘和/或鼻炎的特应性患者被分为三组：A组，由30名从未接受过免疫治疗的患者组成；B组，30名因各种过敏接受免疫治疗3至24个月的患者；C组，30名接受免疫治疗5年或更长时间的患者。使用标准技术进行了以下研究：血清免疫球蛋白浓度IgA、IgG、IgM、类风湿因子、C3和C4浓度、抗核抗体（ANA）的定量测定。通过竞争性免疫酶测定法检测循环免疫复合物。在所研究的组中，对于所考虑的每个参数均未发现统计学差异。尽管不存在自身免疫性疾病的体征和症状，但在整个组中发现ANA的发生率升高（23.3%）。
