Procaccia S, Borroni G, Lanzanova D, Papini E, Perego R, Ferrante P
Boll Ist Sieroter Milan. 1983 Nov 30;62(5):451-61.
In order to contribute to explain the finding of Rheumatoid Factors of the IgG class in all normal subjects, even at low levels, a study on their behaviour in a group of young subjects serving in the army, at the time of anti-typhoid and antitetanic vaccination, and in the following two months, was conducted. Parallely some aspecific serological parameters of autoimmunity were determined. The results demonstrate, first of all, a good antibody response to the vaccine in all subjects observed. Immunoglobulins of the IgG, IgA, and IgM class were normal in all samples. Complement factors C3 and C4 were slightly decreased after the second dose of vaccine, suggesting a modest consumption probably due to immune complexes formation. Factor C3A showed a slight increase, may be to be considered as its property of an acute phase reactant. Autoantibodies determined by immunofluorescence were constantly negative. IgM rheumatoid factors became transitory positive in a significant proportion. IgG rheumatoid factors demonstrated a two-phase increase, more evident after the second dose of vaccine. We can conclude, mainly for the latest parameter, that these results reveal an autoimmune serological response, even quantitatively modest, concomitant to the specific sensitization resulting from vaccination.
为了有助于解释在所有正常受试者中均发现IgG类类风湿因子这一现象，即使其水平较低，我们对一组在军队服役的年轻受试者在接种伤寒和破伤风疫苗时及其后的两个月内类风湿因子的行为进行了研究。同时还测定了一些自身免疫的非特异性血清学参数。结果首先表明，在所有观察的受试者中对疫苗都有良好的抗体反应。所有样本中IgG、IgA和IgM类免疫球蛋白均正常。第二剂疫苗接种后补体因子C3和C4略有下降，提示可能由于免疫复合物形成导致适度消耗。C3A因子略有升高，可能与其作为急性期反应物的特性有关。通过免疫荧光测定的自身抗体始终为阴性。IgM类风湿因子在相当比例的受试者中短暂呈阳性。IgG类风湿因子呈两阶段升高，在第二剂疫苗接种后更为明显。主要基于最新参数，我们可以得出结论，这些结果揭示了一种自身免疫血清学反应，即使在数量上较为适度，也是与疫苗接种导致的特异性致敏相伴发生的。
