Li Tuming, Yan Shuo, Sun Dongmei, Wu Ying, Liang Huazheng, Zheng Qinghu, Zhong Ping
Department of Neurology, Shidong Hospital, 999 Shiguang Road, Yangpu District, Shanghai, 200438 China.
Shanghai Medical College of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
J Diabetes Metab Disord. 2024 Apr 18;23(1):1223-1231. doi: 10.1007/s40200-024-01414-6. eCollection 2024 Jun.
As lifestyle changes, there is an increasing number of type 2 diabetes mellitus (T2DM) patients in China. The present study aimed to investigate the predictive value of the lipid accumulation product (LAP) for T2DM in Chinese elderlies over 65 years.
The present cross-sectional study recruited 2,092 adults from communities of Pudong New Area of Shanghai. Questionnaires were filled and anthropometric and laboratory examinations were completed by all participants. The predictive value of different risk factors for T2DM was analyzed using the receiver operating characteristics curve (ROC).
LAP was found to be closely related to T2DM (adjusted OR: 0.613, 95% CI: 0.581-0.645). Fasting plasma glucose (FPG), LAP, and urea nigrogen (UN) were associated with T2DM in females, whereas FPG, LAP, neck circumference (NC) were associated with T2DM in males. When the cut-off value was 33.8, LAP displayed the optimal predictive performance. A gender difference was observed with an LAP of 37.95 demonstrating the best predictive value in males (AUC = 0.604, 95% CI: 0.577-0.652) and 60.2 in females (AUC = 0.617, 95% CI: 0.574-0.660), respectively.
LAP is more significantly associated with the risk of T2DM in elderlies than FPG, UN or NC, and it serves as a strong predictor of T2DM. However, this is impacted by FPG and neck circumference to a certain extent. Future large-scale studies are needed to confirm its efficacy in predicting diabetes.
随着生活方式的改变，中国2型糖尿病（T2DM）患者数量不断增加。本研究旨在探讨脂质蓄积产物（LAP）对65岁以上中国老年人T2DM的预测价值。
本横断面研究从上海浦东新区社区招募了2092名成年人。所有参与者均填写问卷并完成人体测量和实验室检查。采用受试者工作特征曲线（ROC）分析不同危险因素对T2DM的预测价值。
发现LAP与T2DM密切相关（校正OR：0.613，95%CI：0.581-0.645）。空腹血糖（FPG）、LAP和尿素氮（UN）与女性T2DM相关，而FPG、LAP、颈围（NC）与男性T2DM相关。当临界值为33.8时，LAP显示出最佳预测性能。观察到性别差异，LAP为37.95时在男性中显示出最佳预测价值（AUC = 0.604，95%CI：0.577-0.652），在女性中为60.2（AUC = 0.617，95%CI：0.574-0.660）。
与FPG、UN或NC相比，LAP与老年人T2DM风险的相关性更显著，是T2DM的有力预测指标。然而，这在一定程度上受到FPG和颈围的影响。未来需要大规模研究来证实其在预测糖尿病方面的有效性。
