脂积累产物与 2 型糖尿病风险：一项基于人群的研究。

Lipid accumulation product and type 2 diabetes risk: a population-based study.

机构信息

Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Social Development and Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

BMC Endocr Disord. 2024 Aug 12;24(1):147. doi: 10.1186/s12902-024-01682-6.

DOI:10.1186/s12902-024-01682-6

PMID:39134995

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11318136/

Abstract

BACKGROUND

The Lipid Accumulation Product (LAP) is a measure that indicates excessive fat accumulation in the body. LAP has been the focus of research in epidemiological studies aimed at forecasting chronic and metabolic diseases. This study aimed to evaluate the association between LAP and type 2 diabetes mellitus (T2DM) among adults in western Iran.

METHODS

The study involved 9,065 adults who participated in the initial phase of the Ravansar non-communicable diseases study (RaNCD) cohort. To investigate the association between LAP and T2DM, multiple logistic regressions were employed. Additionally, the receiver operating characteristic (ROC) curve was used to evaluate LAP's predictive ability concerning T2DM.

RESULTS

The participants had an average age of 47.24 ± 8.27 years, comprising 49.30% men and 50.70% women. The mean LAP was 53.10 ± 36.60 for the healthy group and 75.51 ± 51.34 for the diabetic group (P < 0.001). The multiple regression analysis revealed that the odds of T2DM in the second quartile of LAP were 1.69 (95% CI: 1.25, 2.29) times greater than in the first quartile. Furthermore, the odds in the third and fourth quartiles were 2.67 (95% CI: 2.01, 3.55) and 3.73 (95% CI: 2.83, 4.92) times higher, respectively. The ROC analysis for predicting T2DM showed that the LAP index had an area under the curve (AUC) of 0.66 (95% CI: 0.64, 0.68).

CONCLUSION

A strong association was identified between elevated LAP levels and T2DM in the adult population of western Iran. LAP is recommended as a potential tool for screening diabetes susceptibility.

摘要

背景

脂联素（LAP）是一种反映体内脂肪过度堆积的指标。在针对慢性和代谢性疾病进行预测的流行病学研究中，脂联素一直是研究的焦点。本研究旨在评估伊朗西部成年人脂联素与 2 型糖尿病（T2DM）之间的相关性。

方法

本研究纳入了 9065 名参加 Ravansar 非传染性疾病研究（RaNCD）队列初始阶段的成年人。为了研究脂联素与 T2DM 之间的相关性，采用多变量逻辑回归进行分析。此外，还使用了受试者工作特征（ROC）曲线评估脂联素对 T2DM 的预测能力。

结果

参与者的平均年龄为 47.24±8.27 岁，其中 49.30%为男性，50.70%为女性。健康组的平均脂联素水平为 53.10±36.60，糖尿病组为 75.51±51.34（P<0.001）。多变量回归分析显示，脂联素处于第二四分位的个体发生 T2DM 的几率是处于第一四分位的 1.69 倍（95%可信区间：1.25，2.29）。此外，处于第三和第四四分位的几率分别是 2.67 倍（95%可信区间：2.01，3.55）和 3.73 倍（95%可信区间：2.83，4.92）。预测 T2DM 的 ROC 分析显示，脂联素指数的曲线下面积（AUC）为 0.66（95%可信区间：0.64，0.68）。