Hirobumi Ito
Otolaryngology, Ito ENT Clinic, Funabashi, JPN.
Cureus. 2024 Jun 26;16(6):e63182. doi: 10.7759/cureus.63182. eCollection 2024 Jun.
This study investigated the pathogenesis and pathophysiology of chronic epipharyngitis, which presents a variety of symptoms, with a focus on autonomic neuropathy symptoms, and also investigated the literature for information on EAT, which is useful as a treatment method. The mechanism of action of EAT has recently been clarified in terms of its immune system-stimulating and endocrine system-stimulating effects. However, the autonomic nerve-stimulating effects of EAT are still largely unexplained. This study was conducted to collect and integrate previous studies and papers focusing on the autonomic nerve-stimulating effects of EAT and to provide insight into the still not fully elucidated autonomic nerve-stimulating effects of EAT on chronic epipharyngitis. The local stimulating effects of zinc chloride and the bleeding and pain effects of EAT are also summarized, suggesting that EAT exerts its therapeutic effects through the interaction of the immune system, the endocrine system, and the autonomic nervous system. It is important to determine which mechanism is predominantly involved in each case of chronic epipharyngitis and to utilize it in treatment. Elucidating the effects of EAT on the autonomic nervous system will be an important guideline in determining the treatment strategy for chronic epipharyngitis.
本研究调查了具有多种症状的慢性咽炎的发病机制和病理生理学，重点关注自主神经病变症状，还查阅了有关经口电刺激（EAT）的文献，其作为一种治疗方法很有用。最近，EAT的作用机制在其刺激免疫系统和内分泌系统方面已得到阐明。然而，EAT对自主神经的刺激作用在很大程度上仍未得到解释。本研究旨在收集和整合以往关注EAT对自主神经刺激作用的研究和论文，以深入了解EAT对慢性咽炎尚未完全阐明的自主神经刺激作用。还总结了氯化锌的局部刺激作用以及EAT的出血和疼痛作用，表明EAT通过免疫系统、内分泌系统和自主神经系统的相互作用发挥其治疗作用。确定慢性咽炎的每种情况主要涉及哪种机制并将其用于治疗很重要。阐明EAT对自主神经系统的作用将是确定慢性咽炎治疗策略的重要指导原则。
