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硫化氢及其在女性生殖中的作用。

Hydrogen sulfide and its role in female reproduction.

作者信息

Pilsova Aneta, Pilsova Zuzana, Klusackova Barbora, Zelenkova Natalie, Chmelikova Eva, Postlerova Pavla, Sedmikova Marketa

机构信息

Department of Veterinary Sciences, Faculty of Agrobiology, Food, and Natural Resources, Czech University of Life Sciences Prague, Prague, Czechia.

出版信息

Front Vet Sci. 2024 Jun 12;11:1378435. doi: 10.3389/fvets.2024.1378435. eCollection 2024.

DOI:10.3389/fvets.2024.1378435
PMID:38933705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11202402/
Abstract

Hydrogen sulfide (HS) is a gaseous signaling molecule produced in the body by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST). HS is crucial in various physiological processes associated with female mammalian reproduction. These include estrus cycle, oocyte maturation, oocyte aging, ovulation, embryo transport and early embryo development, the development of the placenta and fetal membranes, pregnancy, and the initiation of labor. Despite the confirmed presence of HS-producing enzymes in all female reproductive tissues, as described in this review, the exact mechanisms of HS action in these tissues remain in most cases unclear. Therefore, this review aims to summarize the knowledge about the presence and effects of HS in these tissues and outline possible signaling pathways that mediate these effects. Understanding these pathways may lead to the development of new therapeutic strategies in the field of women's health and perinatal medicine.

摘要

硫化氢（HS）是一种由三种酶在体内产生的气态信号分子：胱硫醚-β-合酶（CBS）、胱硫醚-γ-裂解酶（CSE）和3-巯基丙酮酸硫转移酶（3-MST）。HS在与雌性哺乳动物生殖相关的各种生理过程中至关重要。这些过程包括发情周期、卵母细胞成熟、卵母细胞衰老、排卵、胚胎运输和早期胚胎发育、胎盘和胎膜的发育、妊娠以及分娩发动。尽管如本综述所述，在所有雌性生殖组织中均已证实存在产生HS的酶，但在大多数情况下，HS在这些组织中的具体作用机制仍不清楚。因此，本综述旨在总结关于HS在这些组织中的存在和作用的知识，并概述介导这些作用的可能信号通路。了解这些通路可能会在女性健康和围产医学领域开发出新的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232d/11202402/eafcf380e562/fvets-11-1378435-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232d/11202402/eafcf380e562/fvets-11-1378435-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232d/11202402/53e9fc2cf2e0/fvets-11-1378435-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232d/11202402/6a97167b4968/fvets-11-1378435-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232d/11202402/c922143deb14/fvets-11-1378435-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232d/11202402/2141d07feca9/fvets-11-1378435-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232d/11202402/eafcf380e562/fvets-11-1378435-g005.jpg

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Hydrogen sulfide promotes migration of trophoblast cells by a Rho GTPase mediated actin cytoskeleton reorganization.硫化氢通过Rho GTP酶介导的肌动蛋白细胞骨架重排促进滋养层细胞迁移。
Placenta. 2023 Oct;142:135-146. doi: 10.1016/j.placenta.2023.09.004. Epub 2023 Sep 15.
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ICI 182,780 Attenuates Selective Upregulation of Uterine Artery Cystathionine β-Synthase Expression in Rat Pregnancy.ICI 182,780 可减弱妊娠大鼠子宫动脉胱硫醚 β-合酶表达的选择性上调。
Int J Mol Sci. 2023 Sep 21;24(18):14384. doi: 10.3390/ijms241814384.
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Deficiency of hydrogen sulfide production and pregnancy rate in an experimental model: Association with preterm delivery.
实验模型中硫化氢生成不足与妊娠率：与早产的关联。
Am J Reprod Immunol. 2023 Sep;90(3):e13764. doi: 10.1111/aji.13764.
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Mapping Pregnancy-dependent Sulfhydrome Unfolds Diverse Functions of Protein Sulfhydration in Human Uterine Artery.妊娠相关巯基组图谱揭示了蛋白质巯基化在人子宫动脉中的多种功能。
Endocrinology. 2023 Aug 1;164(9). doi: 10.1210/endocr/bqad107.
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Plasma hydrogen sulfide, nitric oxide, and thiocyanate levels are lower during pregnancy compared to postpartum in a cohort of women from the Pacific northwest of the United States.与产后相比，来自美国西北部太平洋沿岸的一组女性在怀孕期间的血浆硫化氢、一氧化氮和硫氰酸盐水平较低。
Life Sci. 2023 Jun 1;322:121625. doi: 10.1016/j.lfs.2023.121625. Epub 2023 Mar 30.
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Homocysteine increases uterine artery blood flow resistance in women with pregnancy loss.同型半胱氨酸会增加有流产史女性的子宫动脉血流阻力。
J Gynecol Obstet Hum Reprod. 2023 Feb;52(2):102533. doi: 10.1016/j.jogoh.2023.102533. Epub 2023 Jan 4.
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