Amit Z, Brown Z W, Rockman G E
Drug Alcohol Depend. 1977 Sep-Nov;2(5-6):495-500. doi: 10.1016/0376-8716(77)90049-7.
In this study, we examined the possible role of acetaldehyde in the mediation of the reinforcing properties of ethanol. We also examined the possible interaction of acetaldehyde and brain norepinephrine in this mediation. We found that rats will self-administer acetaldehyde delivered into the cerebral ventricles, and that this operant behaviour can be attenuated by injections of a dopamine-beta-hydroxylase inhibitor. The results are discussed in terms of a role for tetrahydroisoquinoline alkaloids in alcoholism.
在本研究中，我们检测了乙醛在介导乙醇强化特性方面可能发挥的作用。我们还检测了乙醛与脑去甲肾上腺素在这一介导过程中可能存在的相互作用。我们发现，大鼠会自行摄入注入脑室的乙醛，并且这种操作性行为可通过注射多巴胺-β-羟化酶抑制剂而减弱。我们根据四氢异喹啉生物碱在酒精中毒中的作用对结果进行了讨论。
