LeSage Mark G, Smethells John R, Harris Andrew C
Department of Medicine, Minneapolis Medical Research Foundation.
Departments of Medicine, University of Minnesota.
Behav Anal (Wash D C). 2018 Aug;18(3):252-274. doi: 10.1037/bar0000113. Epub 2018 Jul 9.
Behavioral pharmacology is a branch of the experimental analysis of behavior that has had great influence in drug addiction research and policy. This paper provides an overview of recent behavioral pharmacology research in the field of tobacco regulatory science, which provides the scientific foundation for the Food and Drug Administration Center for Tobacco Products (FDA CTP) to set tobacco control policies. The rationale and aims of tobacco regulatory science are provided, including the types of preclinical operant behavioral models it deems important for assessing the abuse liability of tobacco products and their constituents. We then review literature relevant to key regulatory actions being considered by the FDA CTP, including regulations over nicotine and menthol content of cigarettes, and conclude with suggesting some directions for future research. The current era of tobacco regulatory science provides great opportunities for behavioral pharmacologists to address the leading cause of preventable death and disease worldwide.
行为药理学是行为实验分析的一个分支，在药物成瘾研究和政策方面产生了重大影响。本文概述了烟草监管科学领域最近的行为药理学研究，该研究为美国食品药品监督管理局烟草制品中心（FDA CTP）制定烟草控制政策提供了科学依据。文中阐述了烟草监管科学的基本原理和目标，包括其认为对评估烟草制品及其成分的成瘾可能性至关重要的临床前操作性行为模型类型。然后，我们回顾了与FDA CTP正在考虑的关键监管行动相关的文献，包括对香烟尼古丁和薄荷醇含量的规定，并最后提出了一些未来研究的方向。当前的烟草监管科学时代为行为药理学家提供了巨大机遇，以应对全球可预防死亡和疾病的首要原因。
