单剂量与五日疗程甲硝唑治疗滴虫病的双盲比较
Double-blind comparison of a single dose and a five-day course of metronidazole in the treatment of trichomoniasis.
作者信息
Thin R N, Symonds M A, Booker R, Cook S, Langlet F
出版信息
Br J Vener Dis. 1979 Oct;55(5):354-6. doi: 10.1136/sti.55.5.354.
Abstract
Although there have been reports of the results of treating trichomoniasis with metronidazole 2 g in a single dose, no randomised double-blind comparison of this treatment with a multiple-dose regimen has been reported. In such a comparison, 96 women were treated with metronidazole 2 g in a single dose and 96 women with metronidazole 400 mg twice daily for five days. Forty-eight of 52 women followed for 14 days after the single dose were cured, as were 61 of 66 women followed for 14 days after the start of the five-day regimen. These results compare favourably with previous reports. Side effects were trivial, and we recommend the single 2-g dose, for it is effective, economical, and can be given under supervision in the clinic.
摘要
尽管已有关于单剂量2克甲硝唑治疗滴虫病结果的报道，但尚未见这种治疗方法与多剂量疗法的随机双盲比较报告。在这样一项比较中，96名妇女接受单剂量2克甲硝唑治疗，96名妇女接受甲硝唑400毫克每日两次、共五天的治疗。单剂量治疗后随访14天的52名妇女中有48名治愈，五天疗程开始后随访14天的66名妇女中有61名治愈。这些结果与先前的报告相比很有利。副作用轻微，我们推荐2克单剂量疗法，因为它有效、经济，且可在诊所监督下给药。
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