Brodziak-Dopierała Barbara, Fischer Agnieszka, Ahnert Bożena
Department of Toxicology, Toxicological Analysis and Bioanalysis, Faculty of Pharmaceutical Science, Medical University of Silesia, Ostrogórska 30 Str. 41-200, Sosnowiec, Poland.
Biol Trace Elem Res. 2025 Mar;203(3):1685-1700. doi: 10.1007/s12011-024-04269-3. Epub 2024 Jun 27.
Current trends are promoting youth, beauty, health, and fitness. Individuals often seek out remedies, such as medicines or dietary supplements (DS), to achieve these goals. However, highly processed foods, chronic stress, and environmental pollution contribute to the development of civilization diseases. The aim of this study was to evaluate the mercury (Hg) content in medicines and DS that are available in Poland. A total of 139 preparations were tested (75 drugs, 64 DS). The medicines contained preparations belonging to antibacterial, antiviral, antifungal; analgesic, antipyretic, and anti-inflammatory; heart and blood vessel disease preventatives; respiratory tract infections treatment; diuretics; aiding digestion; supplements; antidiarrhoeals; anti-allergics; anti-rheumatics; antibiotics; and others. The tested dietary supplements had an effect on the following: improve the condition of skin, hair, and nails; vitamins; minerals; probiotics; weight loss; special for women; and others. The Hg content of the samples was determined using atomic absorption spectrometry (AAS). The Hg content of all the preparations varied widely (0.1-57.4 µg/kg), with a median Hg concentration of 1.2 µg/kg. The median Hg concentration for medicines was 0.8 µg/kg, prescription medicines having higher Hg concentrations (0.9 µg/kg) than over-the-counter (OTC) drugs (0.5 µg/kg). For DS, the Hg content was found to be higher than for drugs, at 2.0 µg/kg. The herbal preparations showed the highest Hg content among the individual DS groups (3.4 µg/kg). The Hg concentrations in the tested drug and DS samples did not exceed acceptable standards. However, if multiple pharmaceutical preparations are taken simultaneously over a long period of time, and there is existing environmental exposure, there is a possibility of Hg concentration accumulation and adverse health effects.
当前趋势推崇青春、美丽、健康和健身。人们常常寻求药物或膳食补充剂等疗法来实现这些目标。然而，高度加工食品、慢性压力和环境污染导致了文明病的发展。本研究的目的是评估波兰市场上药品和膳食补充剂中的汞（Hg）含量。共测试了139种制剂（75种药品、64种膳食补充剂）。药品包括抗菌、抗病毒、抗真菌制剂；止痛、退热和抗炎制剂；心脏和血管疾病预防药物；呼吸道感染治疗药物；利尿剂；助消化药物；补充剂；止泻药；抗过敏药；抗风湿药；抗生素等。测试的膳食补充剂有以下作用：改善皮肤、头发和指甲状况；维生素；矿物质；益生菌；减肥；女性专用；以及其他。使用原子吸收光谱法（AAS）测定样品中的汞含量。所有制剂的汞含量差异很大（0.1 - 57.4微克/千克），汞浓度中位数为1.2微克/千克。药品的汞浓度中位数为0.8微克/千克，处方药的汞浓度（0.9微克/千克）高于非处方药（OTC）（0.5微克/千克）。对于膳食补充剂，汞含量为2.0微克/千克，高于药品。草药制剂在各类膳食补充剂中汞含量最高（3.4微克/千克）。测试的药品和膳食补充剂样品中的汞浓度未超过可接受标准。然而，如果长期同时服用多种药物制剂，并且存在环境暴露，就有可能导致汞浓度积累并对健康产生不良影响。
