Kostev F I
Biull Eksp Biol Med. 1985 Jun;99(6):661-3.
The time-course of changes in the activity of sorbitol dehydrogenase, catalase and the intensity of lipid peroxidation in the blood and kidneys of 250 albino rats was studied in the course of the development of alcoholic dependence when suffering from secondary infection. Litonit, a new antialcoholic drug, was found to be effective for the treatment of infectious inflammatory renal lesions in alcoholism. Unlike teturam, litonit promoted the decrease of sorbitol dehydrogenase and catalase activity in the kidneys and abated the intensity of lipid peroxidation. The possibility of using litonit as one of the remedies of pathogenetic therapy for infectious inflammatory renal lesions in alcoholism is under discussion.
研究了250只白化大鼠在酒精依赖发展过程中继发感染时血液和肾脏中山梨醇脱氢酶、过氧化氢酶活性及脂质过氧化强度的时间变化过程。发现一种新型抗酒精药物立托尼特对治疗酒精中毒性感染性炎症性肾脏病变有效。与戒酒硫不同，立托尼特可使肾脏中山梨醇脱氢酶和过氧化氢酶活性降低，并减轻脂质过氧化强度。目前正在讨论将立托尼特用作酒精中毒性感染性炎症性肾脏病变病因治疗药物之一的可能性。
