Ariaev V L
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(5):756-62.
Experiments on 220 albino rats showed that lithium carbonate, chloride and nicotinate had different capacities to suppress ethanol dependence induced by a three-month administration of alcohol, with lithium nicotinate showing the greatest activity. The efficacy of the drugs correlated with the normalization of the activity of alcohol dehydrogenase, catalase and the levels of nicotinamide coenzymes and lipid peroxides in the brain, liver and kidneys. The drug administration was attended by an increased EEG synchronization, expanded range of perceived frequencies and enhanced synchronization energy. The above changes occurred with all lithium salts, being, however, most prominent with lithium nicotinate.
对220只白化大鼠进行的实验表明，碳酸锂、氯化锂和烟酸锂对抑制因连续三个月饮酒诱导产生的乙醇依赖具有不同的能力，其中烟酸锂的活性最强。这些药物的疗效与大脑、肝脏和肾脏中乙醇脱氢酶、过氧化氢酶的活性以及烟酰胺辅酶和脂质过氧化物水平的正常化相关。给药后脑电图同步性增强，可感知频率范围扩大，同步能量增强。所有锂盐给药后均出现上述变化，但以烟酸锂最为显著。
