Needs C J, Brooks P M
Br J Rheumatol. 1985 Aug;24(3):291-7. doi: 10.1093/rheumatology/24.3.291.
All nonsteroidal anti-inflammatory drugs (NSAIDs) and antirheumatic drugs are likely to be distributed into human milk to some extent; whether they are detected is a function of the assay sensitivity. For minimal infant exposure, the ideal drug for lactating women is one which has a short half-life, is found in minimal quantities in human milk and has inactive metabolites which also are present only in small amounts. In order to reduce the quantity of drug presented to the child, the drug should be taken by the mother at the time of breast-feeding with the next feed occurring after a time period equivalent to one half-life of the drug. Using the above-mentioned criteria, the choice of NSAIDs would be between a short half-life propionic acid derivative, with little biotransformation, such as ibuprofen or flurbiprofen. Diclofenac is also suitable. Gold salts and corticosteroids would seem safe to prescribe. However, the infant should be closely monitored if antimalarials are being used by lactating women.
所有非甾体抗炎药（NSAIDs）和抗风湿药物都可能在一定程度上进入母乳；能否检测到它们取决于检测方法的灵敏度。为使婴儿接触量最小，哺乳期妇女的理想用药应具有半衰期短、母乳中含量极少且其代谢产物无活性且含量也很少的特点。为减少药物进入婴儿体内的量，母亲应在母乳喂养时服药，下次喂奶应在相当于该药物半衰期的时间段之后进行。根据上述标准，NSAIDs的选择应在半衰期短、生物转化少的丙酸衍生物之间，如布洛芬或氟比洛芬。双氯芬酸也适用。金盐和皮质类固醇似乎可以安全开处方。然而，如果哺乳期妇女使用抗疟药，应密切监测婴儿。
