Park S C, Lee C H, Kim S Y, Park C H, Kim T W, Seok S E, Choi H S, Choi H R, Lee M A, Won J S
Clin Ther. 1985;7(4):448-51.
In 45 patients in whom typhoid fever was confirmed by culture of a blood sample, cefotaxime (1 gm BID) was administered intravenously for four days; if defervescence did not occur by day 5, the dosage was increased to 2 gm BID until defervescence, when it was reduced to 1 gm BID until discharge. On average, defervescence occurred on day 7 (range, day 3 to day 14), requiring a total dose of 31 gm (range, 12 to 60 gm) of cefotaxime. Relapse, occurring in three patients, was treated with co-trimoxazole. The duration of cefotaxime therapy was longer than therapy with chloramphenicol but without the risk of bone marrow depression.
在45例血样培养确诊为伤寒热的患者中，静脉注射头孢噻肟（1克，每日两次），持续四天；如果到第5天仍未退热，则剂量增加至2克，每日两次，直至退热，退热后再减至1克，每日两次，直至出院。平均而言，退热发生在第7天（范围为第3天至第14天），头孢噻肟的总剂量为31克（范围为12至60克）。三名患者出现复发，用复方新诺明进行治疗。头孢噻肟治疗的持续时间比氯霉素治疗长，但没有骨髓抑制的风险。
