Putman Ashley K, Contreras G Andres, Sordillo Lorraine M
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 784 Wilson Road, East Lansing, MI 48823, USA.
Antioxidants (Basel). 2021 Jan 20;10(2):145. doi: 10.3390/antiox10020145.
Oxidative stress has been associated with many pathologies, in both human and animal medicine. Damage to tissue components such as lipids is a defining feature of oxidative stress and can lead to the generation of many oxidized products, including isoprostanes (IsoP). First recognized in the early 1990s, IsoP are formed in numerous biological fluids and tissues, chemically stable, and easily measured by noninvasive means. Additionally, IsoP are highly specific indicators of lipid peroxidation and thereby are regarded as excellent biomarkers of oxidative stress. Although there have been many advancements in the detection and use of IsoP as a biomarker, there is still a paucity of knowledge regarding the biological activity of these molecules and their potential roles in pathology of oxidative stress. Furthermore, the use of IsoP has been limited in veterinary species thus far and represents an avenue of opportunity for clinical applications in veterinary practice. Examples of clinical applications of IsoP in veterinary medicine include use as a novel biomarker to guide treatment recommendations or as a target to mitigate inflammatory processes. This review will discuss the history, biosynthesis, measurement, use as a biomarker, and biological action of IsoP, particularly in the context of veterinary medicine.
氧化应激与人类医学和兽医学中的许多病理状况都有关联。对脂质等组织成分的损伤是氧化应激的一个关键特征，并且可能导致包括异前列腺素（IsoP）在内的许多氧化产物的生成。IsoP于20世纪90年代初首次被发现，它在多种生物体液和组织中形成，化学性质稳定，并且可以通过非侵入性方法轻松测量。此外，IsoP是脂质过氧化的高度特异性指标，因此被视为氧化应激的优秀生物标志物。尽管在将IsoP作为生物标志物的检测和应用方面已经取得了许多进展，但关于这些分子的生物活性及其在氧化应激病理学中的潜在作用，仍然缺乏相关知识。此外，到目前为止，IsoP在兽医物种中的应用一直有限，这代表了其在兽医临床应用中的一个机会领域。IsoP在兽医学中的临床应用实例包括用作指导治疗建议的新型生物标志物或作为减轻炎症过程的靶点。本综述将讨论IsoP的历史、生物合成、测量、作为生物标志物的用途以及生物学作用，特别是在兽医学背景下。
