• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

酶控制反应生成用于生物活性分子合成的链烷醇。

Enzyme-controlled reactions giving alkanols of use in the synthesis of biologically active molecules.

作者信息

Roberts S M

出版信息

Ciba Found Symp. 1985;111:31-9. doi: 10.1002/9780470720929.ch4.

DOI:10.1002/9780470720929.ch4
PMID:3893940
Abstract

(+/-)-Bicyclo[3.2.0]hept-2-en-6-one was reduced using a variety of fungi including yeasts. Baker's yeast gave 6-exo-(1R,5S,6S)-bicyclo[3.2.0]hept-2-en-6-ol and 6-endo-(1S,5R,6S)-bicyclo[3.2.0]hept-2-en-6-ol while Curvularia lunata and Mortierella ramanniana gave only the 6-endo-alcohol and optically active bicycloheptenone. The optically active bicycloheptenols were used to prepare prostaglandin F2 alpha in the natural configuration.

摘要

使用包括酵母在内的多种真菌对(+/-)-双环[3.2.0]庚-2-烯-6-酮进行还原。面包酵母生成6-外型-(1R,5S,6S)-双环[3.2.0]庚-2-烯-6-醇和6-内型-(1S,5R,6S)-双环[3.2.0]庚-2-烯-6-醇，而新月弯孢霉和拉曼被孢霉仅生成6-内型醇和旋光性双环庚烯酮。旋光性双环庚烯醇用于制备天然构型的前列腺素F2α。

相似文献

1
Enzyme-controlled reactions giving alkanols of use in the synthesis of biologically active molecules.酶控制反应生成用于生物活性分子合成的链烷醇。
Ciba Found Symp. 1985;111:31-9. doi: 10.1002/9780470720929.ch4.
2
Enantioselective Baeyer-Villiger oxidation of bicyclo[3.2.0]hept-2-en-6-One with fungi: optimization of biotransformation and use of TiO2 as support of cell growth.利用真菌对双环[3.2.0]庚-2-烯-6-酮进行对映选择性拜耳-维利格氧化反应：生物转化的优化以及使用二氧化钛作为细胞生长的载体
Biotechnol Lett. 2006 Jun;28(11):805-10. doi: 10.1007/s10529-006-9000-3. Epub 2006 May 23.
3
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.源自常见手性库的不同对映体纯碳环2'-脱氧核糖核苷类似物的立体选择性合成及抗病毒特性：(+)-(1R,5S)-和(-)-(1S,5R)-2-氧杂双环[3.3.0]辛-6-烯-3-酮
J Med Chem. 1990 May;33(5):1353-60. doi: 10.1021/jm00167a011.
4
Synthesis and in vitro activity of various derivatives of a novel thromboxane receptor antagonist, (+/-)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo[2.2.1] hept-2-exo-yl]heptenoic acid.
J Med Chem. 1988 Sep;31(9):1847-54. doi: 10.1021/jm00117a028.
5
The structures of different diastereomers of bicyclo[2.2.1]hept-5-en-2-yl phenyl sulfoxide.双环[2.2.1]庚-5-烯-2-基苯基亚砜不同非对映异构体的结构。
Acta Crystallogr B. 1989 Feb 1;45 ( Pt 1):93-9. doi: 10.1107/s0108768188009103.
6
Reduction of bicyclo[3.3.1]nonane-2,8-diones with baker's yeast.用面包酵母还原双环[3.3.1]壬烷-2,8-二酮。
Bioorg Med Chem. 1994 Jun;2(6):395-401. doi: 10.1016/0968-0896(94)80006-5.
7
[Stereoisomeric aromatic compounds XIX: Asymmetric reduction of 4(5)-oxocarboxylic acids with baker's yeast].
Z Naturforsch C J Biosci. 1987 Nov-Dec;42(11-12):1159-64.
8
Production of patulin by Micromycetes.
Mycopathologia. 1989 Mar;105(3):129-33. doi: 10.1007/BF00437244.
9
N-substituted 4,7,7-trimethyl-3-(1-piperidinyl)bicyclo-[2.2.1]hept-2-ene 2-carboxamides and 2-carbothioamides with hypotensive activity.具有降压活性的N-取代的4,7,7-三甲基-3-(1-哌啶基)双环-[2.2.1]庚-2-烯-2-甲酰胺和2-硫代甲酰胺
Farmaco Sci. 1985 Feb;40(2):120-3.
10
Synthesis and in vitro activity of stereoisomers of a novel thromboxane receptor antagonist, (+-)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo [2.2.1]hept-2-exo-yl]heptenoic acid.一种新型血栓素受体拮抗剂（±）-（5Z）-7-[3-内-[(苯磺酰基)氨基]双环[2.2.1]庚-2-外-基]庚烯酸的立体异构体的合成及体外活性
J Med Chem. 1990 Mar;33(3):1027-31. doi: 10.1021/jm00165a022.