Xie An-Na, Liu Guo-Yi, Zhang Sun-Zhengyuan, Dai Wei-Wei
Laboratory of Science and Technology Center, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Sheng Li Xue Bao. 2024 Jun 25;76(3):418-428.
Aging refers to a progressive decline in biological functions, leading to age-related diseases and mortality. The transition metals, including iron, copper, and manganese, play important roles in human physiological and pathological processes. Substantial research has demonstrated that senescent cells accumulate higher levels of transition metals, which in turn accelerates the process of cellular senescence and related diseases through mechanisms such as production of excessive reactive oxygen species (ROS), induction of oxidative stress, DNA damage, and mitochondrial dysfunction. This review article provides a comprehensive overview of the causes of transition metal accumulation in senescent cells, as well as the mechanisms by which it further promotes cellular senescence and related diseases. The aim is to provide insights into anti-aging and treatment of aging-related diseases caused by transition metal accumulation.
衰老指的是生物功能的逐渐衰退，导致与年龄相关的疾病和死亡。包括铁、铜和锰在内的过渡金属在人类生理和病理过程中发挥着重要作用。大量研究表明，衰老细胞积累了更高水平的过渡金属，进而通过产生过量活性氧（ROS）、诱导氧化应激、DNA损伤和线粒体功能障碍等机制加速细胞衰老及相关疾病的进程。本文综述全面概述了衰老细胞中过渡金属积累的原因，以及其进一步促进细胞衰老和相关疾病的机制。目的是为抗衰及治疗由过渡金属积累引起的衰老相关疾病提供见解。
