Kong Yahui, Trabucco Sally E, Zhang Hong
Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Mass., USA.
Interdiscip Top Gerontol. 2014;39:86-107. doi: 10.1159/000358901. Epub 2014 May 13.
Aging is characterized by a progressive decline in cellular function, organismal fitness and increased risk of age-associated diseases and death. One potential cause of aging is the progressive accumulation of dysfunctional mitochondria and oxidative damage with age. Considerable efforts have been made in our understanding of the role of mitochondrial dysfunction and oxidative stress in aging and age-associated diseases. This chapter outlines the interplay between oxidative stress and mitochondrial dysfunction, and discusses their impact on senescence, cell death, stem cell function, age-associated diseases and longevity.
衰老的特征是细胞功能逐渐衰退、机体健康状况下降，以及与年龄相关的疾病和死亡风险增加。衰老的一个潜在原因是功能失调的线粒体随着年龄的增长而逐渐积累以及氧化损伤。在理解线粒体功能障碍和氧化应激在衰老及与年龄相关疾病中的作用方面，人们已经付出了巨大努力。本章概述了氧化应激与线粒体功能障碍之间的相互作用，并讨论了它们对衰老、细胞死亡、干细胞功能、与年龄相关疾病和寿命的影响。
