Programa de Genómica Evolutiva, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, México.
mSystems. 2024 Jul 23;9(7):e0058424. doi: 10.1128/msystems.00584-24. Epub 2024 Jun 28.
Over almost three decades, average nucleotide identity (ANI) analysis has been instrumental in operationally defining species in bacteria. However, barely any attention has been paid to soundly defining intra-species units employing ANI analyses until recently. Notably, some very recent publications are good steps forward in that direction. The level of granularity provided by these intra-species units will be relevant to understanding the eco-evolutionary dynamics and transmission of bacterial lineages and mobile genetic elements, antibiotic resistance, and virulence genes. These intra-species units will undoubtedly advance the genomic epidemiology of many bacterial pathogens. In the coming years, we anticipate that many studies will implement ANI-based definitions of different intra-species units, such as strains or sequence types, for many different bacterial species.
在过去的三十年中，平均核苷酸同一性 (ANI) 分析在细菌的操作定义物种方面发挥了重要作用。然而，直到最近才开始关注使用 ANI 分析来合理定义种内单位。值得注意的是，一些最近的出版物在这方面迈出了很好的一步。这些种内单位提供的粒度水平将与理解细菌谱系和移动遗传元件、抗生素耐药性和毒力基因的生态进化动态和传播有关。这些种内单位无疑将推进许多细菌病原体的基因组流行病学。在未来几年，我们预计许多研究将针对许多不同的细菌物种，实施基于 ANI 的不同种内单位（如菌株或序列类型）的定义。
