School of Mechanical Engineering, Iran University of Science and Technology, Tehran 13114-16846, Iran.
Department of Mechanical Engineering, Islamic Azad University, Science and Research branch, Tehran, Iran.
Nanotechnology. 2024 Jul 11;35(39). doi: 10.1088/1361-6528/ad5cfb.
Tissue engineering is a multidisciplinary field that merges engineering, material science, and medical biology in order to develop biological alternatives for repairing, replacing, maintaining, or boosting the functionality of tissues and organs. The ultimate goal of tissue engineering is to create biological alternatives for repairing, replacing, maintaining, or enhancing the functionality of tissues and organs. However, the current landscape of tissue engineering techniques presents several challenges, including a lack of suitable biomaterials, inadequate cell proliferation, limited methodologies for replicating desired physiological structures, and the unstable and insufficient production of growth factors, which are essential for facilitating cell communication and the appropriate cellular responses. Despite these challenges, there has been significant progress made in tissue engineering techniques in recent years. Nanoparticles hold a major role within the realm of nanotechnology due to their unique qualities that change with size. These particles, which provide potential solutions to the issues that are met in tissue engineering, have helped propel nanotechnology to its current state of prominence. Despite substantial breakthroughs in the utilization of nanoparticles over the past two decades, the full range of their potential in addressing the difficulties within tissue engineering remains largely untapped. This is due to the fact that these advancements have occurred in relatively isolated pockets. In the realm of tissue engineering, the purpose of this research is to conduct an in-depth investigation of the several ways in which various types of nanoparticles might be put to use. In addition to this, it sheds light on the challenges that need to be conquered in order to unlock the maximum potential of nanotechnology in this area.
组织工程学是一个跨学科领域，融合了工程学、材料科学和医学生物学，以开发用于修复、替代、维持或增强组织和器官功能的生物替代品。组织工程学的最终目标是创造用于修复、替代、维持或增强组织和器官功能的生物替代品。然而，目前的组织工程技术面临着几个挑战，包括缺乏合适的生物材料、细胞增殖不足、复制所需生理结构的方法有限，以及生长因子的不稳定和不足，这些生长因子对于促进细胞通讯和适当的细胞反应至关重要。尽管存在这些挑战，但近年来组织工程技术取得了重大进展。由于其尺寸变化带来的独特性质，纳米粒子在纳米技术领域中占据着重要地位。这些粒子为组织工程中遇到的问题提供了潜在的解决方案，推动了纳米技术的发展。尽管在过去的二十年中，纳米粒子的应用取得了重大突破，但它们在解决组织工程中的困难方面的全部潜力在很大程度上仍未被开发。这是因为这些进展发生在相对孤立的领域。在组织工程领域，本研究的目的是深入研究各种类型的纳米粒子可能被应用的几种方式。此外，它还揭示了为了充分发挥纳米技术在这一领域的潜力而需要克服的挑战。
