Xia Qipeng, Zhou Shuyan, Zhou Jingya, Zhao Xia, Saif Muhammad Saqib, Wang Jianping, Hasan Murtaza, Zhao Min, Liu Qiang
Yingtan People's Hospital, Nanchang University, Yingtan 335499, PR China.
Medical Faculty of Dalian University of Technology-Yingtan People's Hospital Joint Research Center, Yingtan 335499, PR China.
ACS Biomater Sci Eng. 2025 Apr 14;11(4):1945-1969. doi: 10.1021/acsbiomaterials.4c02118. Epub 2025 Mar 11.
Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional bone grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict their use in clinical settings. A great deal of work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for the regeneration of major lesions has emerged: bone tissue engineering (BTE). BTE involves the use of biomaterials that can imitate the natural design of bone. To yet, no biological material has been able to fully meet the parameters of the perfect implantable material, even though several varieties have been created and investigated for bone regeneration. Against this backdrop, researchers have focused a great deal of interest over the past few years on the subject of nanotechnology and the use of nanostructures in regenerative medicine. The ability to create nanoengineered particles that can overcome the current constraints in regenerative strategies─such as decreased cell proliferation and differentiation, insufficient mechanical strength in biological materials, and insufficient production of extrinsic factors required for effective osteogenesis has revolutionized the field of bone and tissue engineering. The effects of nanoparticles on cell characteristics and the application of biological materials for bone regeneration are the main topics of our review, which summarizes the most recent in vitro and in vivo research on the application of nanotechnology in the context of BTE.
全球约有17.1亿人患有严重的骨骼异常，这是导致残疾的主要原因。传统的骨移植手术存在一些缺点，影响了其治疗效果，并限制了其在临床环境中的应用。人们已经做了大量工作来开发新的、更有效的策略。在这种情况下，一种用于大骨缺损再生的关键技术出现了：骨组织工程（BTE）。骨组织工程涉及使用能够模仿骨自然结构的生物材料。尽管已经开发并研究了几种用于骨再生的生物材料，但到目前为止，还没有一种生物材料能够完全满足理想可植入材料的所有参数。在此背景下，在过去几年中，研究人员对纳米技术以及纳米结构在再生医学中的应用产生了浓厚兴趣。能够制造出纳米工程颗粒，以克服再生策略中当前存在的限制，如细胞增殖和分化减少、生物材料机械强度不足以及有效骨生成所需的外源性因子产生不足，这彻底改变了骨与组织工程领域。纳米颗粒对细胞特性的影响以及生物材料在骨再生中的应用是我们综述的主要主题，该综述总结了纳米技术在骨组织工程背景下应用的最新体外和体内研究。
