Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China.
Institute of Neuroscience, Soochow University, Suzhou 215123, China.
Int J Biol Macromol. 2024 Aug;274(Pt 2):133495. doi: 10.1016/j.ijbiomac.2024.133495. Epub 2024 Jun 27.
Cartilage repair and regeneration have become a global issue that millions of patients from all over the world need surgical intervention to repair the articular cartilage annually due to the limited self-healing capability of the cartilage tissues. Cartilage tissue engineering has gained significant attention in cartilage repair and regeneration by integration of the chondrocytes (or stem cells) and the artificial scaffolds. Recently, polysaccharide-protein based scaffolds have demonstrated unique and promising mechanical and biological properties as the artificial extracellular matrix of natural cartilage. In this review, we summarize the modification methods for polysaccharides and proteins. The preparation strategies for the polysaccharide-protein based hydrogel scaffolds are presented. We discuss the mechanical, physical and biological properties of the polysaccharide-protein based scaffolds. Potential clinical translation and challenges on the artificial scaffolds are also discussed.
软骨修复和再生已成为一个全球性问题，由于软骨组织的自我修复能力有限，全球每年有数百万患者需要手术干预来修复关节软骨。软骨组织工程通过将软骨细胞（或干细胞）和人工支架整合在一起，在软骨修复和再生方面引起了广泛关注。最近，多糖-蛋白质基支架作为天然软骨的人工细胞外基质，表现出独特而有前途的机械和生物学特性。在这篇综述中，我们总结了多糖和蛋白质的修饰方法。介绍了多糖-蛋白质基水凝胶支架的制备策略。我们讨论了多糖-蛋白质基支架的机械、物理和生物学特性。还讨论了人工支架的潜在临床转化和挑战。
