Zhang Yushan, Yu Weihan
Department of Orthopedics, Xinchang Hospital Affiliated to Wenzhou Medical University, Xinchang, Zhejiang, China.
Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Bioeng Biotechnol. 2025 Jul 11;13:1625550. doi: 10.3389/fbioe.2025.1625550. eCollection 2025.
Articular cartilage is difficult to regenerate. It often leads to osteoarthritis after injury, which seriously affects the quality of life of patients. Presently, the clinical treatments of articular cartilage injury have certain limitations. With the development of tissue engineering, cartilage repair becomes possible. Different types of bionic scaffolds have shown great application potential in cartilage repair. We reviewed the characteristics of ideal bionic scaffolds, including biocompatibility, biodegradability, mechanical and structural properties, bioactivity and functionality. We also summarized the latest research progress of different bionic scaffolds in recent years, hoping to provide a reference for the design of bionic scaffolds with stable performance and definite efficacy, and help them to be gradually applied in clinical practice.
关节软骨难以再生。损伤后常导致骨关节炎，严重影响患者生活质量。目前，关节软骨损伤的临床治疗存在一定局限性。随着组织工程的发展，软骨修复成为可能。不同类型的仿生支架在软骨修复中显示出巨大的应用潜力。我们综述了理想仿生支架的特性，包括生物相容性、可降解性、力学和结构性能、生物活性及功能性。我们还总结了近年来不同仿生支架的最新研究进展，希望为设计性能稳定、疗效确切的仿生支架提供参考，并助力其逐步应用于临床实践。
